Chia sẻ bài báo qua Email TỔNG QUAN VỀ CHẤT LƯỢNG DƯỢC LIỆU, THÀNH PHẦN HÓA HỌC VÀ LỰA CHỌN CHẤT ĐÁNH DẤU CHO LOÀI MƯỚP ĐẮNG RỪNG (Momordica charantia L.)
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Ngày nhận bài: 23/08/25 Ngày hoàn thiện: 09/03/26 Ngày đăng: 10/03/26Các tác giả
1. Trần Thanh Hà, Khoa công nghệ chiết xuất - Viện Dược liệu2. Bùi Thị Xuân
, Trung tâm dược liệu Tam Đảo - Viện Dược liệu3. Tô Thị Ngân, Trung tâm dược liệu Tam Đảo - Viện Dược liệu
4. Nguyễn Văn Tâm, Trung tâm dược liệu Tam Đảo - Viện Dược liệu
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[1] B. Joseph and D. Jini, “Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency,” Asian Pacific Journal of Tropical Disease, vol. 3, no. 2, pp. 93-102, 2013, doi: 10.1016/S2222-1808(13)60052-3.
[2] J. K. Grover and S. P. Yadav, “Pharmacological actions and potential uses of Momordica charantia: A review,” Journal of Ethnopharmacology, vol. 93, no. 1, pp. 123–132, 2004, doi: 10.1016/j.jep.2004.03.035.
[3] D. Katiyar, V. Singh, and M. Ali, “Phytochemical and pharmacological profile of Momordica charantia: A review,” Biochemistry and Therapeutic Uses of Medicinal Plants, Discovery Publishing House (New Delhi, India), pp. 1-33, 2017.
[4] National Institute of Medicinal Materials, Medicinal plants and medicinal animals in Vietnam (Volume 2), Science and Technology Publishing House, pp. 506–508, 2006.
[5] T. L. Do, Vietnamese medicinal plants and herbs (6th edition), Medical Publishing House, pp. 879–881, 2015.
[6] T. K. (Ed.). Lim, Edible Medicinal and Non‑Medicinal Plants (Vol. 2), Springer, p. 331, 2012.
[7] C. Hsu, T. H. Tsai, Y. Y. Li, W. H. Wu, C. J. Huang, and P. J. Tsai, “Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes‑induced inflammation,” Food Chemistry, vol. 135, pp. 976–984, 2012, doi: 10.1016/j.foodchem.2012.05.045.
[8] C. H. Tsai, E. C. F. Chen, H. S. Tsay, C. J. Huang, and E. C. Chen, “Wild bitter gourd improves metabolic syndrome: A preliminary dietary supplementation trial,” Nutrition Journal, vol. 11, no. 1, p. 4, 2012.
[9] S. J. Wu and L.T. Ng, “Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) in Taiwan,” LWT‑Food Science and Technology, vol. 41, no. 2, pp. 323-330, 2008, doi: 10.1016/j.lwt.2007.03.003.
[10] K. H. Lu, H. C. Tseng, C. T. Liu, C. J. Huang, J. H. Chyuan, and L. Y. Sheen, “Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses,” Food Function, vol. 5, no. 5, pp. 1027–1037, 2014, doi: 10.1039/c3fo60449g.
[11] E. Basch, S. Gabardi, and C. Ulbricht, “Bitter melon (Momordica charantia): A review of efficacy and safety,” American Journal of Health-System Pharmacy, vol. 60, no. 4, pp. 356–359, 2003, doi: 10.1093/ajhp/60.4.356.
[12] M. M. Lolitkar and M. R. R. Rao, “Pharmacology of a hypoglycaemic principle isolated from the fruits of Momordica charantia Linn,” Indian Journal of Pharmacy, vol. 28, no. 5, pp. 129–133, 1966.
[13] A. Raman and C. Lau, “Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae),” Phytomedicine, vol. 2, no. 4, pp. 349–362, 1996, doi: 10.1016/S0944-7113(96)80080-8.
[14] S. A. Lavale, D. Mathew, S. H. Prasad, and T. Feba Jacob, “Momordica charantia var. muricata Willd is a donor for higher fruit number and yield in bitter gourd breeding,” Plant Genetic Resources, vol. 21, no. 3, pp. 287–290, 2023, doi: 10.1017/S1479262123000734.
[15] D. V. Mai, L. A. T. Do, T. M. B. Sanda, and D. T. Truc, “Survey of botanical characteristics and preliminary chemical composition of wild bitter melon (Momordica charantia L.) grown in An Giang,” Journal of Science and Development Economics, vol. 27, pp. 3–12, 2024, doi:10.64632/jsde.27.2024.360.
[16] T. T. Nguyen, T. M. D. Tran, and M. D. Tran, “Comparison of saponin content in common bitter melon (Momordica charantia L.) and wild bitter melon (Momordica charantia var. abbreviata Ser.),” Journal of Medicinal Materials, vol. 19, no. 3, pp. 45–49, 2014.
[17] N. P. L. Tran, T. K. Do, T. M. Tran, T. D. A. Le, and N. Q. Tran, “Survey of medicinal content and biological activity of extract from wild bitter melon (Momordica charantia var. abbreviata Ser.),” Can Tho University Journal of Science, vol. 60, Natural Science Topics, pp. 340–348, 2021.
[18] T. T. Nguyen, T. T. H. Truong, and T. H. H. Nguyen, “Initial study on chemical composition of wild bitter melon (Momordica charantia var. abbreviata Ser., Cucurbitaceae),” Ho Chi Minh City Medical Journal, vol. 18, no. 2, p. 169, 2014.
[19] H. H. Bui, T. Y. T. Nguyen, and T. Ho, “Evaluation of agronomic characteristics and saponin content of some wild bitter melon (Momordica charantia L. var. abbreviata Ser.) samples collected in the South Central region, Vietnam,” Quy Nhon University Science Journal, vol. 18, no. 5, pp. 43–54, 2024, doi:10.52111/qnjs.2024.18504.
[20] Q. T. Nguyen, T. Q. A. Dinh, T. H. Ha, Q. L. Ha, D. L. Hoang, H. L. Ha, T. X. T. Ngo, and Q. T. Pham, “Survey of saponin content in bitter melon fruit by photometric method,” Journal of Medicinal Materials, vol. 25, no. 2, pp. 111–116, 2020.
[21] U. S. Department of Agriculture, “Balsam-pear (bitter gourd), leafy tips, raw,” Agricultural Research Service. [Online]. Available: https://fdc.nal.usda.gov/food-details/168391/nutrients. [Accessed May 18, 2025].
[22] T. T. D. Truong and M. T. Nguyen, “Study on chemical composition and quality evaluation of wild bitter melon (Momordica charantia L.) in Gia Lai,” Journal of Biotechnology, vol. 19, no. 2, pp. 120–132, 2021.
[23] T. H. Y. Nguyen and V. K. Nguyen, “Determination of charantin content, antioxidant and antimicrobial activity in-vitro of the bitter melon (Momordica charantia) in Thua Thien Hue,” Journal of Medicine and Pharmacy - Hue University of Medicine and Pharmacy, vol. 99, no. 21, pp. 45–50, 2014, doi: 10.34071/jmp.2014.3.14.
[24] T. Q. A. Dinh, Q. T. Pham, and Q. T. Nguyen, “Quantification of saponin in bitter melon fruit by HPLC–PDA,” Journal of Science and Technology, Hung Vuong University, vol. 24, no. 3, pp. 79–85, 2021.
[25] M. E. U. Talukder, A. Jahan, T. B. Emran, S. Islam, A. Rahman, and R. H. Bhuiyan, “In vitro Antioxidant Potential of Momordica charantia Fruit Extracts,” British Journal of Pharmaceutical Research, vol. 3, no. 4, pp. 963–971, 2013.
[26] A. P. Singh and K. D. Saxena, “Lectin from the seeds of wild bitter gourd (Momordica charantia L. var. Jhalri): Isolation and partial characterization,” Biosciences Biotechnology Research Asia, vol. 8, no. 2, pp. 807–812, 2011, doi:10.13005/bbra/947.
[27] M. S. Akhtar, M. A. Athar, and M. Yaqub, “Effect of Momordica charantia on blood glucose level in normal and alloxan-induced diabetic rabbits,” Planta Med., vol. 42, no. 7, pp. 205–212, 1981, doi: 10.1055/s-2007-971629.
[28] M. Gölükçü, R. T. F. Ayas, and N. Çınar, “Some physical and chemical properties of bitter melon (Momordica charantia L.) seed and fatty acid composition of seed oil,” Derim, vol. 31, no. 1, pp. 17–24, 2014.
[29] C. Zhang, H. Chen, and W. Bai, “Characterization of Momordica charantia L. polysaccharide and its protective effect on pancreatic cells injury in STZ-induced diabetic mice,” International Journal of Biological Macromolecules, vol. 115, pp. 45–52, 2018.
[30] Y. Y. Deng, Y. Yi, L. F. Zhang, R. F. Zhang, Y. Zhang, Z. C. Wei, X. J. Tang, and M. W. Zhang, “Immunomodulatory Activity and Partial Characterisation of Polysaccharides from Momordica charantia,” Molecules, vol. 19, pp. 13432–13447, 2014.
[31] S. Poovitha and M. Parani, “Protein extracts from Momordica charantia var. muricata exhibit anti-lipidemic and antioxidant activities in type 2 diabetic rats,” Journal of Food Biochemistry, vol. 44, no. 9, 2025, Art. no. e13370, doi: 10.1111/jfbc.13370.
[32] J. C. Chen, W. Q. Liu, L. Lu, M. H. Qiu, Y. T. Zheng, L. M. Yang, and L. H. Hu, “Kuguacins F–S, cucurbitane triterpenoids from Momordica charantia,” Phytochemistry, vol. 70, no. 1, pp. 133–140, 2009.
[33] H. Okabe, Y. Miyahara, T. Yamauchi, and K. Miyahara, “Studies on the constituents of Momordica charantia L. III. Characterization of momordicosides F₁, F₂, I, K, and L, and momordicines I and II,” Chemical & Pharmaceutical Bulletin, vol. 30, no. 12, pp. 4334–4340, 1982.
[34] L. Harinantenaina, M. Tanaka, S. Takaoka, M. Oda, O. Mogami, M. Uchida, and Y. Asakawa, “Momordica charantia constituents and antidiabetic screening of the isolated major compounds,” Chemical & Pharmaceutical Bulletin, vol. 54, no. 7, pp. 1017–1021, 2006.
[35] S. S. Çiçek, “Momordica charantia L.- Diabetes-Related Bioactivities, Quality Control, and Safety Considerations,” Frontiers in Pharmacology, vol. 13, 2022, Art. no. e904643.
[36] J. Yue, Y. Sun, J. Xu, J. Cao, G. Chen, H. Zhang, X. Zhang, and Y. Zhao, “Cucurbitane triterpenoids from the fruit of Momordica charantia L. and their anti-hepatic fibrosis and anti-hepatoma activities,” Phytochemistry, vol. 157, pp. 21–27, 2019.
[37] N. E. Madala, L. Piater, I. Dubery, and P. Steenkamp, “Distribution patterns of flavonoids from three Momordica species by ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry: a metabolomic profiling approach,” Revista Brasileira de Farmacognosia, vol. 26, no. 4, pp. 507–513, 2016.
[38] T. H. Tsai, W. C. Huang, H. T. Ying, Y. H. Kuo, C. C. Shen, Y. K. Lin, and P. J. Tsai, “Wild bitter melon leaf extract inhibits Porphyromonas gingivalis-induced inflammation: Identification of active compounds through bioassay-guided isolation,” Molecules, vol. 21, no. 4, p. 454, 2016.
[39] T. M. H. Pham, D. H. Ngo, D. N. Ngo, and T. S. Vo, “Investigation of biological activities of wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.),” Biomolecules, vol. 9, no. 6, p. 211, 2019.
[40] M. S. Mahwish, F. Saeed, M.T. Sultan, A. Riaz, S. Ahmed, N. Bigiu, R. Amarowicz, and R. Manea, “Bitter Melon (Momordica charantia L.) Fruit Bioactives Charantin and Vicine: Potential for Diabetes Prophylaxis and Treatment,” Plants, vol. 10, no. 4, p. 730, 2021, doi: 10.3390/plants10040730.
[41] X. Xu, B. Shan, C. H. Liao, J. H. Xie, P. W. Wen, and J. Y. Shi, “Anti-diabetic properties of Momordica charantia var. abbreviata polysaccharide in alloxan-induced diabetic mice,” Carbohydrate Polymers, vol. 126, pp. 60–68, 2015, doi: 10.1016/j.ijbiomac.2015.08.049.
[42] P. B. S. Amarnath, K. U. Kumari, E. Padma, K. Umakrishna, B. V. G. Prasad, P. G. Rao, and V. Sekhar, “Biochemical analysis of wild and cultivated Momordica species,” International Journal of Advanced Biochemistry Research, vol. 8, no. 9, pp. 750–754, 2024.
[43] W. Sucrow, “Über steringlucoside und ein neues stigmastadienol aus Momordica charantia,” Tetrahedron Letters, vol. 26, pp. 2217–2221, 1965.
[44] J. K. Grover, S. Yadav, and V. Vats, “Medicinal plants of India with anti-diabetic potential,” Journal of Ethnopharmacology, vol. 81, no. 1, pp. 81–100, 2002.
[45] S. Patel and A. Rauf, “Edible seeds from Cucurbitaceae family as potential functional foods: Immense promises, few concerns,” Biomedicine & Pharmacotherapy, vol. 91, pp. 330–337, 2017.
[46] J. K. Kim, Y. T. Park, M. D. Uddin, Y. B. Kim, H. Bae, H. H. Kim, W. K. Park, and S. U. Park, “Variation of Charantin Content in Different Bitter Melon Cultivars,” Asian Journal of Chemistry, vol. 26, no. 1, pp. 309–310, 2014.DOI: https://doi.org/10.34238/tnu-jst.13463
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