EVALUATION OF THE FAMOTIDINE ABSORPTION OF CELLULOSE PRODUCED BY ACETOBACTER XYLINUM IN SOME CULTURE MEDIA

Abstract

Famotidine (Fa) is used in the treatment of peptic ulcer and duodenal ulcer as a histamine H₂-receptor antagonist. The low oral bioavailability and short biological half-life of famotidine following oral administration promotes development of a prolonged-release carrier. Bacterial cellulose (BC) has various applications in the biomedical fields and advanced drug delivery systems. BC is produced by Acetobacter xylinum in the standard medium (STM), coconut medium (COM) and rice medium (RIM). Experimental design using an experimental planning method with full element and optimization using the steepest descent method was performed. The results of this study showed that optimization parameters concluding the temperature (20 ^oC), shake mode (180 rpm) and time (120 minutes) for optimal fomatidine absorption of BC. The same BC material, the amount of fomatidine absorbed into BC 0.5 cm in thickness is higher than the BC 1 cm in thickness; the highest was 28.4 mg at BC-STM 0.5 cm in thickness; At least 1 cm in thickness at BC-RIM reached 22.48 mg. As the thickness of 0.5 cm or 1 cm, the highest amount of drug absorbed into the BC-STM reached 28.4 or 25.1 mg and the lowest reached 23.28 or 22.48 mg in BC-RIM.