RESULTS OF AMNIOCENTESIS FOR GENETIC TESTING AT PHU THO OBSTETRICS AND PEDIATRIC HOSPITAL

Abstract

Amniocentesis plays an important role in helping prenatal diagnosticians find the cause as well as determine the relationship between fetal morphological abnormalities and chromosomal lesions, helping to make decisions about treatment attitudes towards pregnancy. A cross-sectional descriptive study was conducted on 52 pregnant women with indications for amniocentesis from June 2023 to August 2024 at Phu Tho Provincial Obstetrics and Pediatrics Hospital. The results of the pregnant women had an average age of 27.1±6.7 (18-43) years. The average gestational age at amniocentesis was 20.2±4.2 (16-32) weeks. Indications for amniocentesis included 40.4% of fetuses with morphological abnormalities, 26.9% of maternal serum screening that was positive, 23.1% of couples that had thalassemia genes, 15.4% of mothers > 35 years old. 100% of amniocentesis cases showed that the amniotic fluid was clear yellow, and no complications occurred. There were 22/52 fetuses with chromosomal abnormalities, accounting for 42.3%; chromosomal abnormalities accounted for 31.8%, chromosomal structural abnormalities accounted for 22.7%, and SEA gene abnormalities accounted for 31.8%. The highest rate of amniocentesis was due to morphological abnormalities in the fetus, followed by positive maternal serum screening and the spouse having the thalassemia gene. Applying multiple combined chromosomal diagnostic methods identified a high rate of fetuses with chromosomal abnormalities.