STUDY ON THE BIOLOGICAL ACTIVITY OF CRUDE EXTRACT FROM ARDISIA SYLVESTRIS PITARD LEAVES FOR THE TREATMENT OF GASTRIC ULCERS IN IN VITRO AND IN VIVO MODELS

Đinh Thị Hoài Thương; Kiều Khánh Kinh; Lê Thị Kim Anh; Nguyễn Cao Cường; Nguyễn Hiếu

doi:10.34238/tnu-jst.12553

STUDY ON THE BIOLOGICAL ACTIVITY OF CRUDE EXTRACT FROM ARDISIA SYLVESTRIS PITARD LEAVES FOR THE TREATMENT OF GASTRIC ULCERS IN IN VITRO AND IN VIVO MODELS

About this article

Received: 11/04/25 Revised: 27/07/25 Published: 27/07/25

Authors

1. Dinh Thi Hoai Thuong , Yersin University of Da Lat
2. Kieu Khanh Kinh, Yersin University of Da Lat
3. Le Thi Kim Anh, Yersin University of Da Lat
4. Nguyen Cao Cuong, Yersin University of Da Lat
5. Nguyen Hieu, Yersin University of Da Lat

Abstract

Gastric ulcer is a common gastrointestinal disorder, while current treatment approaches involving antibiotics and proton pump inhibitors (PPIs) are associated with various side effects and the emergence of drug resistance. Consequently, there is increasing interest in exploring safe and effective natural medicinal products. Ardisia sylvestris Pitard (known as Khoi Nhung) is a medicinal plant rich in flavonoids and saponins, exhibiting anti-inflammatory and gastroprotective effects. However, recent studies have not independently evaluated the biological activities of the plant extract using experimental models. Therefore, this study aimed to investigate the biological activities of the leaf extract of Ardisia sylvestris through two experimental models: in vitro (antibacterial activity against Helicobacter pylori) and in vivo (anti-ulcer activity in Wistar rats). The in vitro results demonstrated that the extract produced an inhibition zone of 16 mm, compared to 35 mm for amoxicillin. In the in vivo model, oral administration of the extract at a dose of 450 mg/kg/day significantly reduced ulcer scores and ulcer indices compared to the model group. The bioactive compounds in the extract were found to inhibit gastric acid secretion and enhance protective mucus production. These findings suggest that the leaf extract of Ardisia sylvestris possesses promising potential in the treatment of gastric ulcers, and may contribute to the development of safe herbal alternatives to conventional pharmacological therapies.

Keywords

Ardisia sylvestris Pitard; Gastric ulcer; Biological activity; In vitro; In vivo

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DOI: https://doi.org/10.34238/tnu-jst.12553

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