Email this article DRUG CARRIER POTENTIAL AND CHARACTERIZATION OF NANO-CELLULOSE 3D-NETWORKS PRODUCED BY ACETOBACTER XYLINUM OF FERMENTED AQUEOUS GREEN TEA EXTRACT
About this article
Received: 06/06/19 Revised: 10/07/19 Published: 09/09/19Authors
Nguyen Xuan Thanh
, Institute of Scientific Research and Applications (ISA) - Hanoi Pedagogical University 2 (HPU2)
Abstract
Nano-cellulose 3D-networks (NA3D) could be produced by Acetobacter xylinum (A. xylinum) living in the fermented aqueous green tea extract. NA3Ds include nano fibers forming networks, which are capable of drug loading to form a prolonged release therapy to improve drug bioavailability. Ranitidine is a gastrointestinal H2 receptor antagonist drug with low bioavailability (50%). In this study, NA3Ds are biosynthesized by A. xylinum in the standard medium (SM), coconut water (CW) and rice water (RW). The NA3Ds obtained from CW, and RW have the same characteristics as the NA3D obtained from the SM, and NA3Ds can be fabricated with the desired thickness and diameter in all three types of culture media. NA3Ds absorbed ranitidine in optimum condition did not differ statistically significantly (p > 0.05) in both ranitidine loading (111.6-116.7 mg) and ranitidine entrapment efficiency (61-63%). The NA3Ds were characterized by using field emission scanning electron microscopes (FE-SEM) and fourier transform infrared (FTIR) spectroscopy. Investigation of the NA3D structure using SEM showed that the cellulose fibers of NA3D-SM and NA3D-CW have a stable structure without structural change when loading drug. The results indicate the potential for using NA3D-SM and NA3D-CW to fabricate the drug delivery system.
Keywords
Full Text:
PDFReferences
[1]. M. C. I. M. Amin, A. Abadi, N. Ahmad, H. Katas, J. A. Jamal, "Bacterial cellulose film coating as drug delivery system: physicochemical, thermal and drug release properties", Sain Malaysiana, Vol. 41, No. 5, pp. 561-568, 2012.
[2]. L. Huang, X. Chen, Nguyen Xuan Thanh, H. Tang, L. Zhang, G. Yang, “Nano-cellulose 3D-networks as controlled-release drug carriers”, Journal of Materials Chemistry B (Materials for biology and medicine), Vol. 1, pp. 2976-2984, 2013.
[3]. V. S. Mastiholimath, P. M. Dandagi, A. P. Gadad, R. Mathews, A. R. Kulkarni, “In vitro and in vivo evaluation of ranitidine hydrochloride ethyl cellulose floating microparticles”, J. Microencapsul., Vol. 25, No. 5, pp. 307-314, 2008.
[4]. H. Chavda, C. Patel, “Chitosan superporous hydrogel composite-based floating drug delivery system: A newer formulation approach”, J. Pharm Bioallied Sci., Vol. 2, No. 2, pp. 124-131, 2010.
[5]. V. C. Hitesh, N. P. Chhaganbhai, “A newer formulation approach: Superporous hydrogel composite-based bioadhesive drug-delivery system”, Asian Journal of Pharmaceutical Sciences, Vol. 5, No. 6, pp. 239-250, 2010.
[6]. G. V. Joshi, B. D. Kevadiya, H. C. Bajaj, “Controlled release formulation of ranitidine-containing montmorillonite and Eudragit E-100”, Drug Dev. Ind. Pharm., Vol. 36, No. 9, pp. 1046-1053, 2010.
[7]. A. Bani-Jaber, I. Hamdan, M. Alkawareek, “The synthesis and characterization of fatty acid salts of chitosan as novel matrices for prolonged intragastric drug delivery”, Arch Pharm Res., Vol. 35, No. 7, pp. 1159-1168, 2012.
[8]. B. Singha, V. Sharmaa, A. Dhiman, M. Devi, “Design of Aloe Vera-Alginate Gastroretentive Drug Delivery System to Improve the Pharmacotherapy”, Polymer-Plastics Technology and Engineering, Vol. 51, No. 12, pp. 1303-1314, 2012.
[9]. B. Arun, Y. Rakesh, P. Satyam, Y. Khushbu, S. Shyam, P. S. Islam, “Drug Release Kinetics of Gastroretentive Rantidine Hydrochloride (RHCL)”, Int. J. Curr. Trend. Pharmacobiol. Med. Sci., Vol. 1, No. 2, pp. 1-12, 2016.
[10]. C. J. Greenwalt, K. H. Steinkraus, R. A. Ledford, “Kombucha, the fermented tea: microbiology, composition, and claimed health effects”, Journal of food protection, Vol. 63, No. 7, pp. 976-981, 2000.
[11]. Nguyen Xuan Thanh, "Isolation of Acetobacter xylinum from Kombucha and application of cellulose material produced by bacteria from some culture media for drug carrier", International Journal of Science and Research (IJSR), Vol. 8, No. 1, pp. 1044-1049, 2019.
[12]. S. Hestrin, M. Schramm, “Synthesis of cellulose by Acetobacter xylinum, 2. Preparation of freeze-dried cells capable of polymerizing glucose tocellulose”, Biochem J., Vol. 58, No. 2, pp. 345-352, 1954.
[13]. Nguyen Thi Diem Chi, Ho Thi Yen Linh, Nguyen Van Thanh, “Study on the culture of Acetobacter xylinum for preparation of bio-membrane used for treatment of burn and skin trauma”, Journal of Medicine Sciences of HCM city, Vol. 6, No. 1, pp. 139-141, 2002.
[14]. Phan Thi Huyen Vy, Bui Minh Thy, Phung Thi Kim Hue, Nguyen Xuan Thanh, Trieu Nguyen Trung, “Optimization of famotidine loaded efficiency for bacterial cellulose material fermented from green tea by response surface methodology and Box-Behnken model”, Pharmaceutical Journal, Vol. 501, No. 58, pp. 3-6, 2018.
[15]. Nguyen Thuy Huong, Phạm Thanh Ho, “Selection of Acetobacter xylinum suitable for use in large scale bacterial cellulose production”, Journal of Genetics & Applied, Vol. 3, pp. 49-54, 2003.
[16]. Huynh Thi Ngoc Lan, Nguyen Van Thanh, “Study on characteristics of bacterial cellulose from Acetobacter xylinum used as burnishing membrane”, Pharmaceutical Journal, Vol. 361, pp. 18-20, 2006.
[17]. Đinh Thi Kim Nhung, Nguyen Thị Thuy Van, Tran Nhu Quynh, “Research on Acetobacter xylinum producing bacterial cellulose for therapeutic purpose of burn wound treatment”, Journal of Science and Technology, Vol. 50, No. 4, pp. 453-462, 2012.
[18]. J. B. P. Ricardo, A. A. P. M. Paula, P. N. Carlos, T. Tito, D. Sara, S. Patrizia, “Antibacterial activity of nanocomposites of silver and bacterial or vegetable cellulosic fibers”, Acta Biomater, 5, pp. 2279-2289, 2009.
[19]. B. Kuswandi, Jayus, T. S. Larasati, A. Abdullah, L. Y. Heng, “Real-time monitoring of shrimp spoilage using on-package sticker sensor based on natural dye of curcumin”, Food Analytical Methods, Vol. 5, No. 4, pp. 881-889, 2012.
[20]. Nguyen Xuan Thanh, “Study of some properties of curcumin loaded 3D-nano-cellulose networks produced by Acetobacter xylinum”, Journal of Science and Technology (Agriculture – Forestry – Medicine & Pharmacy) – Thai Nguyen University, Vol. 184, No. 08, pp. 83-88, 2018.
[21]. Nguyen Xuan Thanh, “Evaluation of the in vivo bioavailability of famotidine loaded 3D-nano-cellulose networks produced by Acetobacter xylinum in some culture media”, VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 34, No. 2, pp. 1-7, 2018.
Refbacks
- There are currently no refbacks.