STUYDING ON ALLELE FREQUENCY ADH1B*2 ENCODING ALCOHOL DEHYDROGENASE 1B AT VIETNAMESE INDIVIDUALS LIVING IN THAI NGUYEN CITY | Yến | TNU Journal of Science and Technology

STUYDING ON ALLELE FREQUENCY ADH1B*2 ENCODING ALCOHOL DEHYDROGENASE 1B AT VIETNAMESE INDIVIDUALS LIVING IN THAI NGUYEN CITY

About this article

Received: 31/05/21                Revised: 13/09/21                Published: 16/09/21

Authors

1. Hoang Thi Thu Yen Email to author, TNU - University of Sciences
2. Nguyen The Kien, Thai Nguyen Medical College

Abstract


Alcohol dehydrogenase 1B (ADH1B) is an enzyme involved mainly alcohol metabolism in humans, there are 3 allele variants affecting the alcohol metabolism of ADH1B (ADH1B*1, ADH1B*2 and ADH1B*3). In which, ADH1B*2 and ADH1B*3 alleles have higher activity in oxidizing alcohol to toxic acetaldehyde than ADH1B*1. In this study, we determined the ADH1B*2 allele frequency in 49 Vietnamese individuals living in Thai Nguyen city, Thai Nguyen province by identifying and analyzing the ADH1B gene sequence. The results showed that, among 49 individuals, there were 5 individuals with homozygous genotype ADH1B*1/ADH1B*1 (10.2%); 29 individuals have the ADH1B*2/ADH1B*2 homozygous genotype (59.2%) and 15 individuals have the ADH1B*1/ADH1B*2 heterozygous genotype (30.6%). Thus, the allele frequencies ADH1B*1 and ADH1B*2 in the study sample group were 25.5% and 74.5%, respectively. The results of this study showed that the gene variants encoding ADH1B for alcohol metabolism (ADH1B*1 and ADH1B*2) in the research group of Vietnamese people have a big difference compared to the published Vietnamese study.

Keywords


Alcohol; Alcohol abuse; Alcohol dehydrogenase; Alcohol dehydrogenase 1B (ADH1B); ADH1B*1 allele; ADH1B*2 allele

References


[1] A. I. Cederbaum, "Alcohol metabolism," Clin Liver Dis, vol. 16, no. 4, pp. 667-685, 2012.

[2] S. Zakhari, "Overview: how is alcohol metabolized by the body?" Alcohol Res Health, vol. 29, no. 4, pp. 245-254, 2006.

[3] T. D. Hurley and H. J. Edenberg, "Genes encoding enzymes involved in ethanol metabolism," Alcohol Res, vol. 34, no. 3, pp. 339-344, 2012.

[4] Alcohol alert, “Alcohol metabolism: an update”, no 72, 2007. [Online]. Available: https://pubs.niaaa.nih.gov/publications/aa72/AA72.pdf. [Accessed Feb. 12, 2020].

[5] P. J. Brooks and S. Zakhari, "Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis," Environ Mol Mutagen, vol. 55, no. 2, pp. 77-91, 2014.

[6] H. K. Seitz and P. Becker, "Alcohol metabolism and cancer risk," Alcohol Res Health, vol. 30, no. 1, pp. 38-47, 2007.

[7] N. Druesne-Pecollo, B. Tehard, Y. Mallet, M. Gerber, T. Norat, S. Hercberg, and P. Latino-Martel, "Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer," Lancet Oncol, vol. 10, no. 2, pp. 173-180, 2009.

[8] W. F. Bosron and T. K. Li, "Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism," Hepatology, vol. 6, no. 3, pp. 502-510, 1986.

[9] V. A. Ramchandani, “Genetics of Alcohol Metabolism,” in: Alcohol, Nutrition, and Health Consequences. Edited by Watson R.R., Preedy, Victor R., Zibadi, Sherma (Eds.): Humana Press, 2013, pp. 15-25.

[10] H. J. Edenberg and J. N. Mcclintick, "Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review," Alcohol Clin Exp Res, vol. 42, no. 12, pp. 2281-2297, 2018.

[11] B. N. Luu and T. T. Nguyen, Consumption of alcohol beverages in Viet Nam - Some national investigation results. National Economics University publishing company, 2018.

[12] A. Iron, A. Groppi, B. Fleury, J. Begueret, A. Cassaigne, and P. Couzigou, "Polymorphism of class I alcohol dehydrogenase in French, Vietnamese and Niger populations: genotyping by PCR amplification and RFLP analysis on dried blood spots," Ann Genet, vol. 35, no. 3, pp. 152-156, 1992.

[13] K. S. Ahn, S. Abdiev, B. Rahimov, Y. Malikov, S. Bahramov, R. Okada, M. Naito, and N. Hamajima, "Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2 Polymorphisms in Uzbekistan," Asian Pac J Cancer Prev, vol. 10, no. 1, pp. 17-20, 2009.

[14] Y. M. Guo, Q. Wang, Y. Z. Liu, H. M. Chen, Z. Qi, and Q. H. Guo, "Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males," World J Gastroenterol, vol. 14, no. 9, pp. 1444-1449, 2008.

[15] K. Matsuo, K. Wakai, K. Hirose, H. Ito, T. Saito, and K. Tajima, "Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects," Cancer Epidemiol Biomarkers Prev, vol. 15, no. 5, pp. 1009-1013, 2006.

[16] H. W. Goedde, D. P. Agarwal, G. Fritze, D. Meier-Tackmann, S. Singh, G. Beckmann, K. Bhatia, L. Z. Chen, B. Fang, and R. Lisker, "Distribution of ADH2 and ALDH2 genotypes in different populations," Hum Genet, vol. 88, no. 3, pp. 344-346, 1992.

[17] K. Yoshimasu, K. Mure, M. Hashimoto, S. Takemura, K. Tsuno, M. Hayashida, K. Kinoshita, T. Takeshita, and K. Miyashita, "Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as indicator of mental disorders in Japanese employees," Alcohol Alcohol, vol. 50, no. 1, pp. 39-45, 2014.

[18] M. Hashibe, J. D. Mckay, M. P. Curado, J. C. Oliveira, S. Koifman, R. Koifman, D. Zaridze, O. Shangina, V. Wunsch-Filho, J. Eluf-Neto, J. E. Levi, E. Matos, P. Lagiou, A. Lagiou, S. Benhamou, C. Bouchardy, N. Szeszenia-Dabrowska, A. Menezes, M. M. Dall'agnol, and F. Merletti, "Multiple ADH genes are associated with upper aerodigestive cancers," Nat Genet, vol. 40, no. 6, pp. 707-709, 2008.

[19] M. Matejcic, M. J. Gunter, and P. Ferrari, "Alcohol metabolism and oesophageal cancer: a systematic review of the evidence," Carcinogenesis, vol. 38, no. 9, pp. 859-872, 2017.

[20] S. Ghosh, B. Bankura, S. Ghosh, M. L. Saha, A. K. Pattanayak, S. Ghatak, M. Guha, S. K. Nachimuthu, C. K. Panda, S. Maji, S. Chakraborty, B. Maity, and M. Das, "Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India," BMC Cancer, vol. 17, no. 1, pp. 782, 2017.




DOI: https://doi.org/10.34238/tnu-jst.4566

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