CHARACTERISTICS PERIPHERAL BLOOD CELLS OF BREAST CANCER PATIENTS AT THAI NGUYEN CENTRAL HOSPITAL | Ngọc | TNU Journal of Science and Technology

CHARACTERISTICS PERIPHERAL BLOOD CELLS OF BREAST CANCER PATIENTS AT THAI NGUYEN CENTRAL HOSPITAL

About this article

Received: 21/02/22                Revised: 27/04/22                Published: 28/04/22

Authors

1. Tran Bao Ngoc Email to author, TNU - University of Medicine and Pharmacy
2. Le Thi Huong Lan, Thai Nguyen National Hospital
3. Nguyen Kieu Giang, TNU - University of Medicine and Pharmacy
4. Cao Thi Minh Phuong, Thai Nguyen National Hospital

Abstract


The research aims to describe the characteristics of peripheral blood cells’ composition in newly diagnosed breast cancer patients. The study was conducted on 80 newly diagnosed breast cancer patients at Thai Nguyen Oncology Center from January 2020 to October 2021 (disease group), 80 healthy people having regular check-ups (control group). Research method was cross-sectional descriptive. The research target is the results of peripheral blood cell tests by medical software. The results obtained were statistically significant (compared to the control group): Increase in monocyte count and decrease in lymphocyte count; Decrease in the number of red blood cells; Slight increase in mean platelet volume. From our study, there is a change in the characteristics of peripheral blood cells’ composition in newly diagnosed breast cancer patients (especially red blood cells).

Keywords


Blood cells; Peripheral; Breast cancer; Composition; Thai Nguyen

References


[1] H. Sung, J. Ferlay, R. L. Siegel et al., “Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries,” CA Cancer J Clin, vol. 71, no. 3, pp. 209-249, 2021, doi: 10.3322/caac.21660.

[2] S. Lukasiewicz, M. Czeczelewski, A. Forma et al., “Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review,” Cancers (Basel), vol. 13, no. 17, 2021, doi: 10.3390/cancers13174287.

[3] Ministry of Health, “Technical process specialized in Hematology-Blood Transfusion-Immunology-Genetics-Molecular Biology,” Decision No. 2017/QD-BYT dated June 9th, 2014 (in Vietnamese), 2014.

[4] L. Li, J. Wang, S. Meng et al., “Peripheral Blood Leukocytes and Platelets Serve as Prognostic Factors in Breast Cancer,” Cancer Biother Radiopharm, vol. 36, vol. 2, pp. 167-173, 2021, doi: 10.1089/cbr.2019.3032.

[5] W. Guo, X. Lu, Q. Liu et al., “Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for breast cancer patients: An updated meta-analysis of 17079 individuals,” Cancer Med, vol. 8, no. 9, pp. 4135-4148, 2019, doi: 10.1002/cam4.2281.

[6] Ministry of Health, “Guidelines for the diagnosis and treatment of breast cancer,” Decision No. 3128/QD-BYT dated July 17th, 2020 (in Vietnamese), 2020.

[7] R. J. Hu, Q. Liu, J. Y. Ma, J. Zhou, and G. Liu, “Preoperative lymphocyte-to-monocyte ratio predicts breast cancer outcome: A meta-analysis,” Clin Chim Acta, vol. 484, pp. 1-6, 2018, doi: 10.1016/j.cca.2018.05.031.

[8] S. Sakuragi, J. Moriguchi, F. Ohashi, and M. Ikeda, “Reference value and annual trend of white blood cell counts among adult Japanese population,” Environ Health Prev Med, vol. 18, no. 2, pp. 143-150, 2013, doi: 10.1007/s12199-012-0304-8.

[9] X. Xie, M. Yao, X. Chen et al., “Reduced red blood cell count predicts poor survival after surgery in patients with primary liver cancer,” Medicine (Baltimore), vol. 94, no. 8, p. e577, 2015, doi: 10.1097/MD.0000000000000577.

[10] F. Ishikawa, K. Miyazono, U. Hellman et al., “Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor,” Nature, vol. 338, no. 6216, pp. 557-562, 1989, doi: 10.1038/338557a0.

[11] J. Paulsson, T. Sjoblom, P. Micke et al., “Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer,” Am J Pathol, vol. 175, no. 1, pp. 334-341, 2009, doi: 10.2353/ajpath.2009.081030.

[12] H. Takeuchi, M. Abe, Y. Takumi et al., “The prognostic impact of the platelet distribution width-to-platelet count ratio in patients with breast cancer,” PLoS One, vol. 12, no. 12, p. e0189166, 2017, doi: 10.1371/journal.pone.0189166.




DOI: https://doi.org/10.34238/tnu-jst.5562

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