ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF AQUEOUS LEAF EXTRACT OF VERNONIA AMYGDALINA DEL, ASTERACEAE

Trương Thị Hồng Nhung; Bùi Sơn Nam; Trần Ngọc Đăng Khoa; Nguyễn Thị Bạch Tuyết; Hoàng Thị Phương Liên

doi:10.34238/tnu-jst.6125

ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF AQUEOUS LEAF EXTRACT OF VERNONIA AMYGDALINA DEL, ASTERACEAE

About this article

Received: 06/06/22 Revised: 16/09/22 Published: 16/09/22

Authors

1. Truong Thi Hong Nhung, Nguyen Tat Thanh University
2. Bui Son Nam, Nguyen Tat Thanh University
3. Tran Ngoc Dang Khoa, Nguyen Tat Thanh University
4. Nguyen Thi Bach Tuyet, Nguyen Tat Thanh University
5. Hoang Thi Phuong Lien , Nguyen Tat Thanh University

Abstract

The anti-inflammatory and analgesic activities of aqueous extract of Vernonia amygdalina Del leaf were investigated in Swiss albino mice. Acetic acid-induced abdominal writhing model was used for studying analgesic activity of the leaf extract. Carrageenan - induced paw oedema was used for studying anti- inflammatory activity of the extract. The extract was administered orally at doses 250 and 500 mg/kg body weight. Analgesic and anti-inflammatory activities of the extract were compared with standard reference drug diclofenac (5 mg/kg) and negative control. The plant extract showed a analgesic effect, with 47.26% and 50.06% inhibition at 250 mg/kg and 500 mg/kg respectively compared to that of the 5 mg/kg standard drug diclofenac which showed 52.86% inhibition (P< 0.05). The results of the anti-inflammatory study revealed that the extract reduced the carragenan-induced oedema significantly (p < 0.05) in comparison to the control group at both dose of 250 mg/kg and 500 mg/kg. The results indicate that the aqueous leaf extract of Vernonia amygdalina Del at dose of 250 mg/kg and 500 mg/kg had the both analgesic and anti-inflammatory effects.

Keywords

Vernonia amygdalina Del.; Analgesic; Anti-inflammatory; Acetic acid; Carrageenan

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DOI: https://doi.org/10.34238/tnu-jst.6125

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