FLAVONOIDS FROM MILLETIA RETICULATA IN VIETNAM | Lê | TNU Journal of Science and Technology

FLAVONOIDS FROM MILLETIA RETICULATA IN VIETNAM

About this article

Received: 12/10/22                Revised: 04/11/22                Published: 08/11/22

Authors

1. Vu Thi Thu Le, TNU - University of Agriculture and Forestry,
2. Ngo Thi Trang, Graduate University of Science and Technology – VAST
3. Nguyen Thi Hue, VNU - University of Science
4. Le Thi Huyen, VNU - University of Science
5. Vu Thanh Dat, Institute of Natural Products Chemistry - VAST
6. Do Tien Lam Email to author, Institute of Natural Products Chemistry - VAST; Graduate University of Science and Technology – VAST
7. Dang Thi Ngoc Ha, TNU - University of Agriculture and Forestry,

Abstract


The plants of the genus Millettia with the main chemical components belonging to the flavonoid group are known to be valuable medicinal herbs and have been widely used in folk remedies. In particular, the species Milletia reticulata Benth has the effect of curing joint pain, rheumatism; treatment of back pain, numbness, pain, injury, blood circulation, etc. From the n-hexane and ethyl acetate fractions of the stem from Milletia reticulata in Lang Son province, three flavonoid compounds have been isolated and determined, including 5-hydroxy-6,7-dimethoxyflavanone (MR1), 4′-methoxytectochrysin (MR2) and pashanone (MR3). Their chemical structures were elucidated by 1D- and 2D-NMR and by comparison with those reported in the literature. This research result is consistent with the main chemical composition of species of the genus Millettia reported.

Keywords


Milletia; Milletia reticulata; Flavonoid; 4′-methoxytectochrysin; Pashanone

References


[1] J. T. Banzouzu, A. Prost, M. RaJemiarimiraho, and P. Ongoka, “Traditional uses of the African Millettia species (Fabaceae),” International Journal of Botany, vol. 4, no. 4, pp. 406-420, 2008.

[2] T. B. Nguyen, Fabaceae family in the List of Plants of Vietnam. Agriculture Publishing House, 2003.

[3] V. C. Vo, Dictionary of Vietnamese Medicinal Plants. Publishing House Medicine, 2012.

[4] H. B. Do, Q. C. Dang, X. C. Bui, T. D. Nguyen, T. D. Do, V. H. Pham, N. L. Vu, D. M. Pham, K. M. Pham, T. T. Doan, T. Nguyen, and T. Tran, The medicinal plants and animals in Vietnam. Science and Technology Publishing House, 2004.

[5] J. W. Kamau, “Phytochemistry and Biological activity of the root extract of Millettia oblata,” Degree Master of Science (Medicinal Chemistry), Jomo Kenyatta University of Agriculture and Technology, 2002.

[6] A. C. Rana and B. Gulliya, “Chemistry and Pharmacology of Flavonoids- A Review,” Indian Journal of Pharmaceutical Education and Research, vol. 53, no. 1, pp. 8-20, 2019.

[7] T.-Y. Wang, Q. Li, and K.-S. Bi, “Review-Bioactive flavonoids in medicinal plants: Structure, activity and biological fate,” Asian Journal of Pharmaceutical Sciences, vol. 13, no. 1, pp. 12-23, 2018.

[8] S.-C. Fang, C.-L. Hsu, H.-T. Lin, and G.-C. Yen, “Anticancer Effects of Flavonoid Derivatives Isolated from Millettia reticulata Benth in SK-Hep-1 Human Hepatocellular Carcinoma Cells,” Journal of Agricultural and Food Chemistry, vol. 58, no. 2, pp. 814-820, 2010.

[9] K. P. P. Nguyen, Methods for isolating organic compounds. National University Ho Chi Minh City Publishing House, 2007.

[10] D. T. Nguyen, The basis of spectral methods applied in chemistry. Science and Technics Publishing House, 2011.

[11] D. T. Nguyen, Spectroscopic methods in organic chemistry. Hanoi National University Publishing House, 2010.

[12] T. T. T. Tran, D. Q. Tran, T. H. A. Nguyen, and V. S. Tran, “Chemical constituents of Miliusa sinensis Finet et Gagnep. (Annonaceae). Part 1 – Flavonoides,” Vietnam Journal of Chemistry, vol. 47, no. 6, pp. 745-748, 2009.

[13] H. Yoon, S. Eom, J. Hyun, G. Jo, D. Hwang, S. Lee, Y. Yong, J. C. Park, Y. H. Lee, and Y. Lim, “1H and 13C NMR Data on Hydroxy/methoxy Flavonoids and the Effects of Substituents on Chemical Shifts,” Bull. Korean Chem. Soc., vol. 32, no. 6, pp. 2101-2107, 2011.

[14] J. C. Romero-Benavides, G. C. Ortega-Torres, J. Villacis, S. L. Vivanco-Jaramillo, K. I. Galarza-Urgilés, and N. Bailon-Moscoso, “Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia,” International Journal of Medicinal Chemistry, vol. 2018, pp. 1-5, 2018, Art. no. 8908435.

[15] R. Mangoyi, J. Midiwo, and S. Mukanganyama, “Isolation and characterization of an antifungal compound 5-hydroxy-7,4’-dimethoxyflavone from Combretum zeyheri,” BMC Complement Altern Med., vol. 15, 2015, Art. no. 405.

[16] A. Hailemariam, M. Feyera, T. Deyou, and N. Abdissa, “Antimicrobial Chalcones from the Seeds of Persicaria lapathifolia,” Biochem Pharmacol (Los Angel), vol. 7, 2018, Art. no. 237, doi: 10.4172/2167-0501.1000237.

[17] C.-S. Yoon, H. Lee, Z. Liu, H.-K. Lee, and D.-S. Lee, “Effects of Compounds Isolated from Lindera erythrocarpa on Anti-Inflammatory and Anti-Neuroinflammatory Action in BV2 Microglia and RAW264.7 Macrophage,” Int. J. Mol. Sci., vol. 23, 2022, Art. no. 7122, doi: 10.3390/ijms 23137122.

[18] S. N. Lo´pez, M. G. Sierra, S. J. Gattuso, R. L. Furlan, and S. A. Zacchino, “An unusual homoisoflavanone and a structurally-relateddihydrochalcone from Polygonum ferrugineum (Polygonaceae),” Phytochemistry, vol. 67, pp. 2152-2158, 2006.

[19] A. V. Kurkina, T. Ryasanova, and K. V. Alexandrovich, “Flavonoids from the Aerial Part of Polygonum hydropiper,” Chemistry of Natural Compounds, vol. 49, no. 5, 2013, doi: 10.1007/s10600-013-0758-y.

[20] R. Kubinova, R. Porizkova, T. Bartl, A. Navratilova, A. Čizek, and M. Valentova, “Biological activities of polyphenols from Polygonum lapathifolium,” Bol Latinoam Caribe Plant Med Aromat, vol. 13, no. 6, pp. 506-516, 2014.




DOI: https://doi.org/10.34238/tnu-jst.6646

Refbacks

  • There are currently no refbacks.
TNU Journal of Science and Technology
Rooms 408, 409 - Administration Building - Thai Nguyen University
Tan Thinh Ward - Thai Nguyen City
Phone: (+84) 208 3840 288 - E-mail: jst@tnu.edu.vn
Based on Open Journal Systems
©2018 All Rights Reserved