EVALUATION OF THE THERAPEUTIC SUPPORT POTENTIAL  OF COMPOUND ON HYPERTENSION CONTAINED IN CHAYOTE  (Sicyos edulis Jacq.) USING MOLECULAR DOCKING METHOD

Trần Đại Luật; Cao Bá Cường; La Việt Hồng; Bùi Thùy Liên

doi:10.34238/tnu-jst.9388

EVALUATION OF THE THERAPEUTIC SUPPORT POTENTIAL OF COMPOUND ON HYPERTENSION CONTAINED IN CHAYOTE (Sicyos edulis Jacq.) USING MOLECULAR DOCKING METHOD

About this article

Received: 11/12/23 Revised: 10/06/24 Published: 11/06/24

Authors

1. Tran Dai Luat , Hanoi Pedagogical University 2
2. Cao Ba Cuong, Hanoi Pedagogical University 2
3. La Viet Hong, Hanoi Pedagogical University 2
4. Bui Thuy Lien, Hoa Lu University

Abstract

Hypertension is a pathological cause of the pressure’s blood flow increase highly. Blood pressure increases durability, which is a risk of cerebrovascular accident, which is an early catastrophe reason in the world. Anhydrase carbonic II in human is a metalloenzyme that catalyzes a reversible hydrate process from CO₂ to HCO₃^-. Thus, inhibiting enzyme CAII is a significant method of treating hypertension. In this case study, molecular docking manner was used to screen compounds contained in Sechium edule (Jacq.,) have effect on hypertension treatment. After screening progress, 9 potential compounds have changes to apply to the drug for hypertension including: Cucurbitacin Dihydro B, Cucurbitacin D, Cucurbitacin-22-deoxo D, Cucurbitacin-22-deoxoiso D, Cucurbitacin E(alpha elaterin), Cucurbitacin Dihydro E, Cucurbitacin G, Cucurbitacin H(24-epi G), Cucurbitacin J.

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DOI: https://doi.org/10.34238/tnu-jst.9388

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