EVALUATION OF THE NEUROSUPPRESSIVE AND ANALGESIC EFFECTS OF THE FLOWER EXTRACTS (PLUMERIA OBTUSA L. APOCYNACEAE)

Võ Thị Thu Hà; Dương Thị Ngọc Linh; Võ Hiền Nhật; Lê Anh Khang; Nguyễn Ngọc Trâm; Nguyễn Thị Thu Hiền

doi:10.34238/tnu-jst.9740

EVALUATION OF THE NEUROSUPPRESSIVE AND ANALGESIC EFFECTS OF THE FLOWER EXTRACTS (PLUMERIA OBTUSA L. APOCYNACEAE)

About this article

Received: 20/02/24 Revised: 14/05/24 Published: 20/05/24

Authors

1. Vo Thi Thu Ha , Nguyen Tat Thanh University
2. Duong Thi Ngoc Linh, Nguyen Tat Thanh University
3. Vo Hien Nhat, Nguyen Tat Thanh University
4. Le Anh Khang, Nguyen Tat Thanh University
5. Nguyen Ngoc Tram, Nguyen Tat Thanh University
6. Nguyen Thi Thu Hien, Nguyen Tat Thanh University

Abstract

Plumeria obtusa L. Apocynaceae is a woody plant with beautiful and fragrant flowers. Traditionally, flowers of this plant are used to treat insomnia, sprains or arthritis. This study aimed to evaluate the neuro- suppressive and analgesic effects of the flower extracts of Plumeria obtusa in mice. The flowers were collected from Ho Chi Minh city and then extracted with 90% alcohol by percolation method. Neuro suppressive and analgesic effects are carried out according to the Rota-Rod method and the model of dipping the tail in hot water. The study showed that the flower extracts at doses of 250 mg/kg and 500 mg/kg body weight per oral decreased the endurance time of mice on the Rota-Rod. The time taken for the tail to flick was recorded at 30, 60, 90 minutes. The results indicated that there was a statistically significant difference between test and control. Thus, the extract of Plumeria obtusa flowers exhibits neurosuppressive and analgesic effects in animal models.

Keywords

Plumeria obtuse; Analgesic; Neurosuppressive; Rota-Rod; Dipping the tail

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DOI: https://doi.org/10.34238/tnu-jst.9740

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