SYNTHESIS, CYTOTOXIC ACTIVITY OF EPITHELIAL CANCER OF SOME ,-UNSATURATED KETONES FROM p-CRESOL

Abstract

2-hydroxy-5-methylacetophenon was prepared by Fries rearrangement reaction of  4-methylphenylacetate ester by catalysis of Lewis acids. Then this intermediate compound was transformed by condensation with aromatic aldehydes to form a series of new α,β-unsaturated ketones (3 compounds). The structure of these products were confirmed by IR, ¹H NMR, ¹³C NMR, HSQC, HMBC and MS spectroscopic data. The biological activities of these compounds have been inves.