Email this article CO-PRECIPITATION MICROWAVE-ASSISTED SYNTHESIS OF Fe3O¬4 NANOPARTICLES FOR DRUG DELIVERY SYSTEM
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Received: 06/03/19 Published: 08/03/19Authors
1. Le Thi Thu Huong
, Vietnam National University of Agriculture, Institute of Materials Science - VAST2. Le Mai Huong, Institute of Natural Product Chemistry - VAST
3. Tran Thi Hong Ha, Institute of Natural Product Chemistry - VAST
4. Pham Hong Nam, Institute of Materials Science - VAST
5. Ha Phuong Thu, Institute of Materials Science - VAST
Abstract
In this study, Fe3O4 magnetic nanoparticles were prepared by the co-precipitation of Fe3+ and Fe2+ with the assistant of microwave (MW) irradiation. The crystal and magnetic properties of the Fe3O4 particles obtained from different conditions of microwave reaction were examined. The prepared magnetic nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission and scanning electron microscopy (TEM & SEM), X-ray powder diffraction (XRD), vibrating sample magnetometer (VSM) and Dynamic Light Scattering (DLS). After that, the optimized Fe3O4 magnetic nanoparticles (size of 10-15 nm, the saturation magnetization of 69 emu/g, and zeta potential of 40.1 mV) were surface modified by alginate polymer and attached with a cancer drug Doxorubicin. The magnetic inductive heating effects and anticancer activities of the nano drug system showed that the synthesis of Fe3O4 with microwave-assistant maintains both physical and biological properties of the material.
Keywords
microwave assisted synthesis; coprecipitation; Fe3O4 nanoparticles; drug delivery system;, Doxorubicin
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