EVALUATION OF REPRODUCTION ABILITY OF ZEBRAFISH – AN ANIMAL MODEL FOR BIOMEDICAL RESEARCH- IN THE BREEDING CONDITION OF HANOI UNIVERSITY OF PHARMACY

Vũ Thị Hồng Hạnh; Lương Thị Thanh Huyền; Nguyễn Anh Vũ

doi:10.34238/tnu-jst.10834

EVALUATION OF REPRODUCTION ABILITY OF ZEBRAFISH – AN ANIMAL MODEL FOR BIOMEDICAL RESEARCH- IN THE BREEDING CONDITION OF HANOI UNIVERSITY OF PHARMACY

About this article

Received: 29/07/24 Revised: 27/03/25 Published: 28/03/25

Authors

1. Vu Thi Hong Hanh , Hanoi University of Pharmacy
2. Luong Thi Thanh Huyen, Hanoi University of Pharmacy
3. Nguyen Anh Vu, Hanoi University of Pharmacy

Abstract

Preclinical testing using animal models has become one of the compulsory examinations for a new drug. Zebrafish has been applied as an outstanding vertebrate model for preclinical testing with different advantages. This study aimed to examine the effect of nutrition conditions and fertilization conditions on the reproduction ability of zebrafish. The zebrafish were kept in a circulating system with different conditions and then selected for breeding. The reproduction ability of zebrafish was evaluated based on the number of embryos and the fertilized eggs from 1 hour to 120 hours after fertilization. The result showed that system maintenance (27±1°C, pH 7 ±0,1; 10 hours light/14 hours dark), feeding twice a day, and breeding at 8 am were the best for the reproduction ability of zebrafish. The result of this study suggested that the breeding of zebrafish are potential to develop the zebrafish as the animal model for biomedical research.

Keywords

Zebrafish; Nutrition condition; Fertilization condition;; Reproduction ability; Zebrafish embryos

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DOI: https://doi.org/10.34238/tnu-jst.10834

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