INVESTIGATION OF THE BIOMEDICAL PROPERTIES OF SrTiO3:Er3+/ Yb3+ THIN FILMS ON TITANIUM FOR BIOMEDICAL IMPLANT APPLICATIONS

Nguyễn Thị Thanh Tuyền; Nguyễn Thị Mai Anh; Lê Tiến Hà; Tạ Quốc Tuấn; Trần Văn Hướng; Phạm Hùng Vượng

doi:10.34238/tnu-jst.10839

INVESTIGATION OF THE BIOMEDICAL PROPERTIES OF SrTiO3:Er3+/ Yb3+ THIN FILMS ON TITANIUM FOR BIOMEDICAL IMPLANT APPLICATIONS

About this article

Received: 30/07/24 Revised: 07/10/24 Published: 08/10/24

Authors

1. Nguyen Thi Thanh Tuyen, Hanoi University of Science and Technology (HUST)
2. Nguyen Thi Mai Anh, Hanoi University of Science and Technology (HUST)
3. Le Tien Ha, TNU - University of Sciences
4. Ta Quoc Tuan, 1) Hanoi University of Science and Technology (HUST), 2) School of Materials Science and Technology, HUST
5. Tran Van Huong, Hanoi University of Science and Technology (HUST)
6. Pham Hung Vuong , 1) Hanoi University of Science and Technology (HUST), 2) School of Materials Science and Technology, HUST

Abstract

In this study, SrTiO₃:Er³⁺/Yb³⁺ thin films on titanium were fabricated by the hydrothermal method at 200°C for biomedical implant applications. Rare earth ions Er³⁺ and Yb³⁺ were codoped into the SrTiO₃ host matrix by fixing the Er³⁺ concentration and varying the Yb³⁺ concentration. The structure and properties of the films were characterized by X-ray diffraction (XRD), and scanning electron microscopy (SEM). The perovskite-structured material coating was annealed at 800°C. The material forms flake-like structures with a fairly uniform size, with a flake thickness of about 2-5 nm and a flake size of about 3-6 μm. Surface properties were investigated by contact angle measurement. The SrTiO₃:Er³⁺/Yb³⁺ material exhibited significantly higher wettability compared to Ti. A confocal laser scanning microscope (CLSM) confirmed good adhesion of kidney cells to the test samples after 48 hours of culture. The results indicate that the SrTiO₃:Er³⁺/Yb³⁺ thin films possess promising biomedical properties, making them suitable for biomedical implants.

Keywords

The hydrothermal; SrTiO3; Cell adhesion; Contact angle; Titanium

Full Text:

PDF (Tiếng Việt)

References

[1] A. R. Benrekia, N. Benkhettou, A. Nassour, M. Driz, M. Sahnoun, and S. Lebègue, “Structural, electronic and optical properties of cubic SrTiO₃ and KTaO₃: Ab initio and GW calculations,” Phys. B Condens. Matter, vol. 407, no. 13, pp. 2632-2636, 2012.

[2] S. Saha, T. P. Sinha, and A. Mookerjee, “Contact us My IOPscience Structural and optical properties of paraelectric SrTiO₃ Structural and optical properties of paraelectric SrTiO₃,” Quantum, vol. 12, pp. 3325-3336, 2000.

[3] J. Wang, S. Yin, M. Komatsu, Q. Zhang, F. Saito, and T. Sato, “Preparation and characterization of nitrogen doped SrTiO₃ photocatalyst,” J. Photochem. Photobiol. A Chem., vol. 165, no. 1-3, pp. 149-156, 2004.

[4] Y. Xu et al., “Review of doping SrTiO₃ for photocatalytic applications,” Bull. Mater. Sci., vol. 46, no. 1, pp. 1-14, 2023.

[5] S. Sahoo, A. Sinha, V. K. Balla, and M. Das, “Synthesis, characterization, and bioactivity of SrTiO₃-incorporated titanium coating,” J. Mater. Res., vol. 33, no. 14, pp. 2087-2095, 2018

[6] Y. Wang, D. Zhang, C. Wen, and Y. Li, “Processing and Characterization of SrTiO₃-TiO₂ Nanoparticle-Nanotube Heterostructures on Titanium for Biomedical Applications,” ACS Appl. Mater. Interfaces, vol. 7, no. 29, pp. 16018-16026, 2015.

[7] A. Escobar et al., “Strontium Titanate (SrTiO₃) Mesoporous Coatings for Enhanced Strontium Delivery and Osseointegration on Bone Implants,” Adv. Eng. Mater., vol. 21, no. 7, pp. 1-8, 2019.

[8] A. K. Dubey, B. Basu, K. Balani, R. Guo, and A. S. Bhalla, “Multifunctionality of perovskites BaTiO₃ and CaTiO₃in a composite with hydroxyapatite as orthopedic implant materials,” Integr. Ferroelectr., vol. 131, no. 1, pp. 119-126, 2011.

[9] R. Pazik, A. Ziecina, B. Poźniak, M. Malecka, L. Marciniak, and R. J. Wiglusz, “Up-conversion emission and in vitro cytotoxicity characterization of blue emitting, biocompatible SrTiO₃ nanoparticles activated with Tm³⁺ and Yb³⁺ ions,” RSC Adv., vol. 6, no. 45, pp. 39469-39479, 2016.

[10] Y. L. Yang and N. Guo, “In situ fabrication and wettability of Ca₂SiO₄/CaTiO₃ biocoating by laser cladding technology on Ti-6Al-4V alloy,” Mater. Sci. Technol. (United Kingdom), vol. 29, no. 5, pp. 598-604, 2013.

[11] M. Kon, R. Sultana, E. Fujihara, K. Asaoka, and T. Ichikawa, “Calcium Titanate Film-Coating on Titanium with Hydrothermal Treatments,” Key Eng. Mater., vol. 330-332, pp. 737-740, 2007.

[12] D. H. Quan et al., “Synthesis of TiO₂ Nanotubes for Improving the Corrosion Resistance Performance of the Titanium Implants,” VNU J. Sci. Math. - Phys., vol. 38, no. 4, pp. 61-68, 2022.

DOI: https://doi.org/10.34238/tnu-jst.10839

Refbacks

There are currently no refbacks.



Remember me