QUANTIFICATION OF PRECURSORS OF METAMPHETAMINE AND  4,3-DIMETHYLENOXYMETAMPHETAMINE IN WASTEWATER BY GC-MS/MS

Đặng Thị Ngọc Lan; Bùi Lê Vân; Vũ Ngân Bình; Trần Nguyên Hà

doi:10.34238/tnu-jst.11066

QUANTIFICATION OF PRECURSORS OF METAMPHETAMINE AND 4,3-DIMETHYLENOXYMETAMPHETAMINE IN WASTEWATER BY GC-MS/MS

About this article

Received: 05/09/24 Revised: 21/01/25 Published: 22/01/25

Authors

1. Dang Thi Ngoc Lan, Hanoi University of Pharmacy
2. Bui Le Van, Hanoi University of Pharmacy
3. Vu Ngan Binh, Hanoi University of Pharmacy
4. Tran Nguyen Ha , Hanoi University of Pharmacy

Abstract

In synthetic narcotics, amphetamine type stimulants (ATS) are the most commonly produced and used group. The analysis of precursors in wastewater of manufacturing nacortics is the basis for indicating the possibility of illegal drug production facilities. This scientific tool will contribute to the area investigation quickly, accurately and effectively. In this study, the GC-MS/MS method was used to simultaneously quantify 7 precursors of metamphetamine and 4,3-dimethylenoxymetamphetamine. The analytical conditions: column HP5-MS 30 m, heli carrier gas with flow rate 1.2 ml/min, temperature gradient program; sample injection volume 1 μl, vaporization chamber temperature 260ºC. Mass spectral conditions: power temperature 230ºC, Filament current 35 mA; Quad 1 temperature: 150ºC, Quad 2 temperature: 150ºC, and MRM. The method was validated according to AOAC 2016 guidelines: system suitability (RSD < 1.6%), specificity, linearity (R>0.994), LOD (5 - 50 ppb) and LOQ (15 - 100 ppb), repeatability (RSD < 11%) and recovery (80.16% - 105.33%) all satisfactory.

Keywords

Amphetamine; MET; MDMA; GC-MS/MS; Wastewater

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References

[1] UNODC, World Drug Report 2021, pp. 71-77, 2021.

[2] Police Investigation Department, "Expanding large drug projects, arresting masterminds and leaders," 2023. [Online]. Available: https://cand.com.vn/Hoat-dong-LL-CAND/mo-rong-cac-chuyen-an-ma-tuy-bat-giu-cac-doi-tuong-chu-muu-cam-dau-i697805/. [Accessed March 2024].

[3] R. Gallagher, R. Shimmon, and A. M. McDonagh, "Synthesis and impurity profiling of MDMA prepared from commonly available starting materials," Forensic Sci. Int., vol. 223, no. (1-3), pp. 306-313, 2012.

[4] F. M. Hauser, J. W. Hulshof, et al., "Characterisation of aqueous waste produced during the clandestine production of amphetamine following the Leuckart route utilising solid-phase extraction gas chromatography-mass spectrometry and capillary electrophoresis with contactless conductivity detection," Drug Test Anal., vol. 10, no. 9, pp. 6-7, 2018.

[5] A. Ciesielski, A. Veitenheimer, et al., "Detection of One Pot Methamphetamie Laboratories via Wastewater Sampling," National Institute of Justice, pp. 183-211, 2020.

[6] T. T. H. Tran, Q. Z. Qiuda, T. K. A. Nguyen, N. B. Vu, et al., "Prevalence of illicit drug consumption in a population of Hanoi: an estimation using wastewater-based epidemiology," Sci. Total Environ., vol. 815, no. 1, p. 152724, 2022.

[7] T. T. L. Nguyen, N. H. Tran, X. T. Nguyen, et al., "Analysis of methamphetamin and cutting agents in wastewater using ultraperformance liquid chromatography tandem mass spectrometry (UPLC -MS/MS),” (in Vietnamese), Journal of Analytical Sciences, vol. 27, no. 3/2022, pp. 66-70, 2022.

[8] AOAC, Guidelines for Standard Method Performance Requirements, AOAC International, 2016.

[9] EC, Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results, Office Journal of the European Commission, 2002.

DOI: https://doi.org/10.34238/tnu-jst.11066

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