CURCUMIN DRUG RELEASING OF CaTiO3 FILM ON Ti FOR  POTENTIAL APPLICATION IN BIOMEDICINE

Nguyễn Thị Thanh Tuyền; Nguyễn Duy Hùng; Lê Tiến Hà; Vũ Đan Vy; Phạm Hùng Vượng

doi:10.34238/tnu-jst.11293

CURCUMIN DRUG RELEASING OF CaTiO3 FILM ON Ti FOR POTENTIAL APPLICATION IN BIOMEDICINE

About this article

Received: 11/10/24 Revised: 13/11/24 Published: 13/11/24

Authors

1. Nguyen Thi Thanh Tuyen, Hanoi University of Science and Technology (HUST)
2. Nguyen Duy Hung, Hanoi University of Science and Technology (HUST)
3. Le Tien Ha, TNU - University of Science
4. Vu Dan Vy, Hanoi University of Science and Technology (HUST)
5. Pham Hung Vuong , 1) Hanoi University of Science and Technology (HUST) 2) School of Materials Science and Technology - HUST

Abstract

A CaTiO₃ coating on a Ti substrate was fabricated by a hydrothermal method at 200°C for 24 hours. The Ca element in the material is an essential component in bone, enhancing biocompatibility. The structure and properties of the material were characterized by X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM). The process of drug loading and release of curcumin was conducted in phosphate-buffered saline (PBS). The curcumin drug loading ability of the CaTiO₃ membrane was recorded by confocal laser scanning microscopy (CLSM). The release of curcumin was studied by an enzyme-linked immunosorbent assay (ELISA) over 72 hours. The results of curcumin releasing showed that the percentage of curcumin releasing was 69.32% compared to the initial amount. This study suggests that the CaTiO₃ coating on a Ti substrate has potential applications in biomedicine.

Keywords

CaTiO3; Hydrothermal synthesis; Curcumin; PBS solution; Ti

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DOI: https://doi.org/10.34238/tnu-jst.11293

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