THE CORRELATION BETWEEN RF, ANTI-CCP WITH CLINICAL AND SUBCLINICAL CHARACTERISTICS OF RHEUMATOID ARTHRITIS PATIENTS

Abstract

Rheumatoid arthritis is a chronic autoimmune arthritis with the basic damage in the synovial membrane of the joints. RF and Anti - CCP plasma immunoassays have been included in the European League Against Rheumatism (EULAR) 2010 as a standard for diagnosing the disease. This study aims to investigate the correlation between RF, Anti-CCP and the clinical, subclinical characteristics of rheumatoid arthritis patients at Hospital A - Thai Nguyen province in 2024. A cross-sectional descriptive study was carried out on 36 patients diagnosed with rheumatoid arthritis according to ACR 1987 at Hospital A - Thai Nguyenprovince. Results showed that of the 36 patients tested for RF, 97.22% had high RF positive, 88,89% of patients tested for Anti-CCP were high positive (> 3 times increase). There was a correlation between RF concentration and VAS score with statistical significance (p = 0.019), the median increased with the level of VAS score. There was a correlation between Anti-CCP concentration and 3 clinical indexes VAS, DAS, Ritchie (p < 0.01). There was a correlation between RF, Anti-CCP concentration and the number of painful joints (p < 0.01) and the number of swollen joints (p < 0.05). There was not a correlation between RF, Anti-CCP concentration and VSS, CRP, HGB. There was a strong correlation between RF and Anti-CCP.