FORMULATION OF DILTIAZEM PELLET BY LAYERING METHOD  IN FLUID-BED MACHINE

Nguyễn Duy Thư

doi:10.34238/tnu-jst.12048

FORMULATION OF DILTIAZEM PELLET BY LAYERING METHOD IN FLUID-BED MACHINE

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Received: 14/02/25 Revised: 03/04/25 Published: 03/04/25

Authors

Nguyen Duy Thu , TNU - University of Medicine and Pharmacy

Abstract

In this research, the pellet containing diltiazem HCl has been initially studied by layering method in fluid-bed machine. The formulation of the pellets included avicel, lactose, binders and diltiazem. Pellets containing ditiazem was prepared by layering drugs and excipients on the inert core which was prepared in rotary processor. The diltiazem pellets were coated with the layering drugs containing ditiazem in fluid-bed machine to obtain pellets. The prepared pellets were evaluated for drug content, particle size, subjected to Scanning Electron Microscopy (SEM) and Differential Scanning Calori metry (DSC), and evaluated for in vitro release. Diltiazem pellets achieved good sphericity, low friability, narrow particle size distribution, smooth surface, high efficiency and be able to control release the drug well. From the research results, we have developed a formula for preparing diltiazem pellets by the fluidized bed coating method from inert cores and standards for pellets as a semi-finished product for capsule or tablet filling or extended-release formulation.

Keywords

Diltiazem; Pellet; Layering; Fluid-bed; formulation

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DOI: https://doi.org/10.34238/tnu-jst.12048

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