PLASMA HOMOCYSTEIN IN HEMODIALYSIS PATIENTS WHO WERE GIVEN SUPPLEMENTATION FOLIC ACID AND VITAMIN B

Abstract

Hyperhomocysteinemia is common in end stage renal disease. Objective: 1) Assess the effect homocysteine lowering of folic acid, vitamin B₁₂, vitamin B₆ in hemodialysis patients. Method: A cross-sectional study of 63 hemodialysis patients, who divided into two groups. Group 1: Included 32 hemodialysis patients, not given daily supplementation of vitamin. Group 2: Included 31 hemodialysis patients, given daily supplementation of 30 mg folic acid, 100mg vitamin B₆ and 1mg of vitamin B₁₂. Plasma Hcy and some other tests were measured at baseline, at 3 months. Result: At baseline, at 3 months, the plasma Hcy in group 1 were 38.4±20.5 µmol/L and  39.0±19.4  µmol/L, respectively. Plasma Hcy levels decreased significantly in group 2, from 39.0±17.0 µmol/L to 28.8±13.2 µmol/L at 3 months (p<0.05) Conclussion: Daily supplementation of vitamin can be reduced plasma Hcy levels.