INVESTIGATION OF THE CHEMICAL COMPOSITION, ANTI-CANCER, AND ANTI-DIABETES ACTIVITIES OF THE ETHANOLIC EXTRACT FROM THE LEAVES OF Tanacetum parthenium (L.) Sch.Bip. CULTIVATED IN GREENHOUSES IN DA LAT, VIETNAM

Hoàng Thị Bình; Võ Văn Nghĩa

doi:10.34238/tnu-jst.12225

INVESTIGATION OF THE CHEMICAL COMPOSITION, ANTI-CANCER, AND ANTI-DIABETES ACTIVITIES OF THE ETHANOLIC EXTRACT FROM THE LEAVES OF Tanacetum parthenium (L.) Sch.Bip. CULTIVATED IN GREENHOUSES IN DA LAT, VIETNAM

About this article

Received: 06/03/25 Revised: 04/04/25 Published: 04/04/25

Authors

1. Hoang Thi Binh , Dalat University
2. Vo Van Nghia, Tay Nguyen Research Center of Medicinal Materials - National Institute of Medicinal Materials

Abstract

Tanacetum parthenium (L.) Sch.Bip., a species native to the Balkan Peninsula, is extensively cultivated in Europe, China, the Netherlands, Japan, and other regions for ornamental and medicinal purposes. In Vietnam, it is primarily grown in Lam Dong and Lao Cai for ornamental purposes, while its medicinal potential remains largely unexplored. Therefore, no studies have yet investigated the chemical composition and biological activity of T. parthenium extracts cultivated in Vietnam. This study aims to assess the phytochemical profile, and the anti-cancer and anti-diabetic activities of the extract from T. parthenium leaves. Qualitative analysis identified the presence of flavonoids, glycosides, cardiac glycosides, tannins, terpenoid-steroids, and saponins. In biological activity assays, the T. parthenium extract exhibited significant inhibitory effects against various cancer cell lines, including epithelial carcinoma (KB), liver cancer (HepG2), breast cancer (MCF-7), and A549 lung cancer (A549). Conversely, the extract showed no significant inhibition of the α-glucosidase enzyme at tested concentrations up to 256 µg/mL. These findings underscore the potential of cultivating T. parthenium in Da Lat as a medicinal plant for developing novel cancer therapies.

Keywords

Anti-cancer; Anti-diabetic; Da Lat; Ethanol extract; Tanacetum parthenium

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DOI: https://doi.org/10.34238/tnu-jst.12225

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