PHYTOCHEMICAL SCREENING AND ANALGESIC EFFECT  OF EXTRACTS FROM FRUIT PEEL Musa acuminata Colla., MUSACEAE

Võ Thị Thu Hà

doi:10.34238/tnu-jst.12350

PHYTOCHEMICAL SCREENING AND ANALGESIC EFFECT OF EXTRACTS FROM FRUIT PEEL Musa acuminata Colla., MUSACEAE

About this article

Received: 19/03/25 Revised: 04/04/25 Published: 04/04/25

Authors

Vo Thi Thu Ha , Nguyen Tat Thanh University

Abstract

Wild banana (Musa acuminata Colla. Musaceae) is a medicinal herb widely used in traditional medicine but people often only use the flesh and discard the peel. Research on phytochemical screening and the analgesic effect of fruit peel Musa acuminata extracts aims to provide scientific data for reusing a potential medicinal resource in Vietnam. After drying, the fruit peel was extracted with 70^o alcohol. The peripheral analgesic effect was investigated in writhing model with acetic acid, the central analgesic effect was examinated in immersion model. Qualitative results determined the presence of compounds in peel extract: organic acids, flavonoids, proanthocyanosides, saponins, tannins, essential oils and triterpenoids. The extract at doses of 250 mg/kg and 500 mg/kg showed peripheral analgesic effects. A central analgesic effect was shown when using the 500 mg/kg dose. The study showed that wild banana peel extract. displayed central and peripheral analgesic effects in the experimental model.

Keywords

Musa acuminata; Analgesic; Acetic acid; Acute toxicity; Phytochemical

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References

[1] V. C. Vo, Vietnamese Dictionary of Medicinal Plants, (in Vietnamese), Medical Publishing House, Ha Noi, vol. 1, 2018, pp. 437-438.

[2] T. H. C. Nguyen, “Study on extraction and determination of chemical composition in some extracts of wild banana (Musa Acuminata Colla) in the Central Highlands,” (in Vietnamese), Msc Thesis, Da Nang University, 2015.

[3] T. Abad, G. McNaughton-Smith, W.Q. Fletcher et al., "Isolation of (S)-(+)-naproxene from Musa acuminata. Inhibitory effect of naproxene and its 7-methoxy isomer on constitutive COX-1 and inducible COX-2," Planta Medica, vol. 66, no. 5, pp. 471-473, 2000.

[4] E. Genatrika, V. N. H. Laksari, and T. Tjiptasurasa, “Antidiabetic activity of Musa Acuminata Colla fruit peel (MACFP) ethanol extract in glucose-induced diabetic rats,” MATEC Web of Conferences, EDP Sciences, 2018, Art. no. 07007.

[5] P. Tamri, A. Hemmati, A. Amirahmadi et al., "Evaluation of wound healing activity of hydroalcoholic extract of banana (Musa acuminata) fruit’s peel in rabbit," Fharmacology Line, vol. 3, pp. 203-208, 2016.

[6] F. C. Abdullah, L. Rahimi, Z. A. Zakaria et al., "Hepatoprotective, antiulcerogenic, cytotoxic and antioxidant activities of Musa acuminata peel and pulp," Novel Plant Bioresources: Applications in Food, Medicine Cosmetics, vol. 1, pp. 371-382, 2014.

[7] Y. Subramaniam, N. Mazlan, H. Hassan et al., “Antimicrobial Activity of Musa acuminata Peel Extract against Gram-Positive Bacteria,” International Journal of Life Sciences and Biotechnology, vol. 3, no. 2, pp. 191-196, 2020.

[8] S. Chauhan, K.C. Sindhu, M. Bhandari et al., “Phytochemical Profiling and Biological Activities of Musa acuminata Peel with Antioxidant and α-Amylase Inhibitory Effects,” Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry, vol. 1, no. 6, pp. 9-14, 2025.

[9] L. P. Yuei, N. Singaram, and H. Hassan, "Study of anti‐inflammatory and analgesic activity of Musa spp. peel," Health and Life Sciences, vol. 1, pp. 48-54, 2016.

[10] S. A. E. Sawi, H. F. Aly, A. Sleem et al., "Potent Therapeutic Effects of Polysaccharides Isolated from Some Edible Plant Wastes: Characterization and Bioactivities," Egyptian Journal of Chemistry, vol. 65, no. 131, pp. 1401-1416, 2022.

[11] I. Ciulei, "Methodology for analysis of vegetable drugs", Practical Manual on the industrial Utilisation of Medicinal and Aromatic Plants Center Building, Romania, 1982, pp. 67-81.

[12] G. F. Pavao-de-Souza, A. C. Zarpelon, G. C Tedeschi et al., "Acetic acid-and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI3K and microglia in mice," Pharmacology Biochemistry Behavior., vol. 101, no. 3, pp. 320-328, 2012.

[13] T. D. Do, Anti-inflammatory analgesics and pharmacological research methods, (in Vietnamese), Medical Publishing House, 2017, pp. 427-608.

[14] F. Bashir, A. Hassan, A. Mushtaq et al., "Phytochemistry and antimicrobial activities of different varieties of banana (Musa acuminata) peels available in Quetta city," Polish Journal of Environmental Studies, vol. 30, no. 2, pp. 1531-1538, 2021.

DOI: https://doi.org/10.34238/tnu-jst.12350

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