CLINICAL AND PARACLINICAL CHARACTERISTICS OF THREATENED PRETERM LABOR CASES AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL

Cao Thị Quỳnh Anh; Nguyễn Thị Hồng; Lê Đức Thọ; Đỗ Tuấn Đạt

doi:10.34238/tnu-jst.12381

CLINICAL AND PARACLINICAL CHARACTERISTICS OF THREATENED PRETERM LABOR CASES AT HANOI OBSTETRICS AND GYNECOLOGY HOSPITAL

About this article

Received: 24/03/25 Revised: 17/07/25 Published: 17/07/25

Authors

1. Cao Thi Quynh Anh, TNU - University of Medicine and Pharmacy
2. Nguyen Thi Hong , TNU - University of Medicine and Pharmacy
3. Le Duc Tho, TNU - University of Medicine and Pharmacy
4. Do Tuan Dat, 1) Hanoi University of Medicine and Pharmacy, 2) Hanoi Obstetrics and Gynecology Hospital

Abstract

Preterm birth is a major cause of neonatal morbidity and mortality, with an increasing global incidence. Early identification of risk factors and timely intervention are crucial in improving perinatal outcomes. This study aims to describe the clinical and paraclinical characteristics of pregnant women diagnosed with threatened preterm labor between 28 and 34 weeks of gestation at Hanoi Obstetrics and Gynecology Hospital from September to December 2024. A cross-sectional descriptive study was conducted on 110 hospitalized pregnant women. The average maternal age was 28.78 ± 5.09 years, with a majority living in urban areas (56%) and working in administrative or office jobs (44.5%). A history of preterm birth was recorded in 11.8% of cases, while 58.2% were primigravida. The mean gestational age at presentation was 30.19 ± 2.05 weeks, with 71.8% of cases between 28 and 31 weeks. Common symptoms included abdominal pain (95.5%), vaginal or cervical infections (65.5%), and uterine contractions on obstetric monitoring (79.1%). Notably, cervical shortening (≤ 25 mm) was found in 82.7% of cases, with a mean cervical length of 19.50 ± 7.86 mm. These findings highlight the importance of cervical length measurement in predicting preterm birth risk and emphasize the need for targeted interventions to improve maternal and neonatal outcomes.

Keywords

Preterm birth; Cervical length; Threatened preterm labor; Vaginal infections; Uterine contractions

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References

[1] H. Blencowe et al., “National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications,” Lancet Lond. Engl., vol. 379, no. 9832, pp. 2162–2172, Jun. 2012, doi: 10.1016/S0140-6736(12)60820-4.

[2] L. J. Salomon et al., “ISUOG practice guidelines: Performance of first-trimester fetal ultrasound scan,” Ultrasound Obstet. Gynecol. Off. J. Int. Soc. Ultrasound Obstet. Gynecol., vol. 41, no. 1, pp. 102–113, Jan. 2013, doi: 10.1002/uog.12342.

[3] J. Klumper, A. C. J. Ravelli, C. Roos, A. Abu-Hanna, and M. A. Oudijk, “Trends in preterm birth in the Netherlands in 2011–2019: A population-based study among singletons and multiples,” Acta Obstet. Gynecol. Scand., vol. 103, no. 3, pp. 449–458, 2024, doi: 10.1111/aogs.14684.

[4] E. O. Ohuma et al., “National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis,” Lancet Lond. Engl., vol. 402, no. 10409, pp. 1261–1271, Oct. 2023, doi: 10.1016/S0140-6736(23)00878-4.

[5] Unicef Vietnam, “World Prematurity Day: 15 million preterm babies worldwide need profound attention,” 2024. [Online]. Available: https://www.unicef.org/vietnam. [Accessed Mar. 17, 2024].

[6] T. M. Luu, S. L. Katz, P. Leeson, B. Thébaud, and A.-M. Nuyt, “Preterm birth: Risk factor for early-onset chronic diseases,” CMAJ Can. Med. Assoc. J. J. Assoc. Medicale Can., vol. 188, no. 10, pp. 736–746, Jul. 2016, doi: 10.1503/cmaj.150450.

[7] A. Chainoglou, K. Chrysaidou, V. Kotsis, and S. Stabouli, “Preterm birth, kidney function and cardiovascular disease in children and adolescents,” Child. Basel Switz., vol. 9, no. 8, Jul. 2022, Art. no. 1130, doi: 10.3390/children9081130.

[8] H. Chehade, U. Simeoni, J.-P. Guignard, and F. Boubred, “Preterm birth: Long term cardiovascular and renal consequences,” Curr. Pediatr. Rev., vol. 14, no. 4, pp. 219–226, 2018, doi: 10.2174/1573396314666180813121652.

[9] D. Q. Bui, “Study on clinical and paraclinical characteristics and cervical secretion Interleukin-8 levels in pregnant women with threatened preterm birth at Hanoi Obstetrics and Gynecology Hospital,” Master's thesis in Medicine, Hanoi Medical University, 2014.

[10] T. T. Hua, “Evaluation of the effectiveness of the PartoSure test in predicting preterm labor at the National Hospital of Obstetrics and Gynecology,” Master's thesis in Medicine, Hanoi Medical University, 2017.

[11] G. Bhan et al., “Informal work and maternal and child health: A blind spot in public health and research,” Bull. World Health Organ., vol. 98, no. 3, pp. 219–221, Mar. 2020, doi: 10.2471/BLT.19.231258.

[12] R. L. Copper et al., “The preterm prediction study: Maternal stress is associated with spontaneous preterm birth at less than thirty-five weeks’ gestation," Am. J. Obstet. Gynecol., vol. 175, no. 5, pp. 1286–1292, Nov. 1996, doi: 10.1016/s0002-9378(96)70042-x.

[13] T. L. Nguyen, "Clinical Symptoms, Paraclinical Findings, and Treatment Outcomes of Threatened Preterm Labor at Hung Yen Obstetrics and Pediatrics Hospital," Master's Thesis in Medicine, Hanoi Medical University, 2024.

[14] B. M. Mercer et al., “The preterm prediction study: effect of gestational age and cause of preterm birth on subsequent obstetric outcome," Am. J. Obstet. Gynecol., vol. 181, no. 5, pp. 1216–1221, Nov. 1999, doi: 10.1016/s0002-9378(99)70111-0.

[15] N. T. Phan, “Study on cervical length in pregnant women with threatened preterm birth at 28–32 weeks using transperineal ultrasound,” Master's thesis in Medicine, Hanoi Medical University, 2011.

[16] V. Q. Truong, “Study on the predictive value of the Bishop score and cervical length measured by ultrasound for preterm birth," Residency Thesis, Hanoi Medical University, 2013.

[17] N. Tabatabaei et al., “Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: A case-control study,” BJOG Int. J. Obstet. Gynaecol., vol. 126, no. 3, pp. 349–358, Feb. 2019, doi: 10.1111/1471-0528.15299.

[18] Society for Maternal-Fetal Medicine (SMFM), J. McIntosh, H. Feltovich, V. Berghella, and T. Manuck, “The role of routine cervical length screening in selected high- and low-risk women for preterm birth prevention,” Am. J. Obstet. Gynecol., vol. 215, no. 3, pp. B2-7, Sep. 2016, doi: 10.1016/j.ajog.2016.04.027.

[19] A. Palatnik, E. S. Miller, M. Son, and M. A. Kominiarek, “The association between maternal obesity, cervical length, and preterm birth,” Am. J. Perinatol., vol. 34, no. 5, pp. 471–479, Apr. 2017, doi: 10.1055/s-0036-1593350.

DOI: https://doi.org/10.34238/tnu-jst.12381

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