ASSOCIATION BETWEEN MUC1 AND PSCA SINGLE-GENE POLYMORPHOMYS WITH CHRONIC GASTRITIS AND NON-CHRONIC GASTRITIS

Nguyễn Tiến Dũng; Bùi Thị Thu Hương; Hoàng Thị Ngọc Trâm

doi:10.34238/tnu-jst.12476

ASSOCIATION BETWEEN MUC1 AND PSCA SINGLE-GENE POLYMORPHOMYS WITH CHRONIC GASTRITIS AND NON-CHRONIC GASTRITIS

About this article

Received: 03/04/25 Revised: 23/06/25 Published: 23/06/25

Authors

1. Nguyen Tien Dung, TNU – University of Medicine and Pharmacy
2. Bui Thi Thu Huong, TNU – University of Medicine and Pharmacy
3. Hoang Thi Ngoc Tram , TNU – University of Medicine and Pharmacy

Abstract

Chronic gastritis is a chronic lesion of the epithelium covering the gastric mucosa and has the risk of developing into gastric cancer. The current trend is to find susceptible genes that increase the risk of gastric cancer and to study the single nucleotide polymorphism of the MUC1 gene and the PSCA gene because most of the single nucleotide polymorphism have been found to be associated with gastric cancer. With the aim of studying the association between MUC1 and PSCA single gene polymorphisms with the chronic gastritis group and the non-chronic gastritis group, we conducted a study on 86 patients with chronic gastritis (disease group) and 50 patients without chronic gastritis (control group) from October 2022 to June 2023. Using the cross-sectional descriptive method, we obtained the following results: The genotype rs4072037 of the MUC1 gene and the genotype rs2294008 of the PSCA gene in the chronic gastritis and non-chronic gastritis groups were statistically significantly different (p < 0.05). People with the AA genotype had a higher risk of chronic gastritis than people with the AG genotype with OR = 3.3 (p < 0.05; 95%CI: 1.67 – 6.5) and the AG+GG genotype with OR = 3.0 (p < 0.05; 95%CI: 1.59 – 5.69). People with the TT genotype had a higher risk of chronic gastritis than people with the CT genotype with OR = 4.4 (p < 0.05; 95%CI: 1.5 – 13.1) and the CT+CC genotype with OR = 4.9 (p < 0.05; 95%CI: 1.7 – 13.8).

Keywords

Chronic gastritis; Genotype; Single nucleotide polymorphism; MUC1 gene; PSCA gene

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DOI: https://doi.org/10.34238/tnu-jst.12476

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