INVESTIGATION OF ACUTE TOXICITY, PHYTOCHEMICAL CONSTITUENTS, AND ANALGESIC EFFECTS OF THE EXTRACT FROM RUELLIA TUBEROSA L. (ACANTHACEAE)

Nguyễn Thị Thùy Trang; Phạm Lê Hoàng Uyên; Nguyễn Việt Trung

doi:10.34238/tnu-jst.12974

INVESTIGATION OF ACUTE TOXICITY, PHYTOCHEMICAL CONSTITUENTS, AND ANALGESIC EFFECTS OF THE EXTRACT FROM RUELLIA TUBEROSA L. (ACANTHACEAE)

About this article

Received: 04/06/25 Revised: 02/12/25 Published: 02/12/25

Authors

1. Nguyen Thi Thuy Trang , Nguyen Tat Thanh University
2. Pham Le Hoang Uyen, Nguyen Tat Thanh University
3. Nguyen Viet Trung, Nguyen Tat Thanh University

Abstract

Ruellia tuberosa L. (Acanthaceae), commonly known as "popping pod," is a herbaceous plant native to tropical regions of the Americas and is now widely cultivated in various countries. In Vietnam, this species has traditionally been used in folk medicine for the treatment of ailments such as the common cold, fever, urinary bladder stones, and musculoskeletal pain. However, studies on the safety profile of R. tuberosa grown in Vietnam remain limited. The present study aimed to evaluate the acute toxicity and both central and peripheral analgesic effects of R. tuberosa extract collected from Tien Giang Province. Phytochemical screening revealed the presence of bioactive compounds including alkaloids, flavonoids, anthocyanosides, proanthocyanidins, tannins, organic acids, and polyuronic compounds. In acute toxicity assessment, the extract was classified as practically non-toxic based on standard toxicity scales. Furthermore, oral administration of the extract at doses of 250 mg/kg and 500 mg/kg produced peripheral analgesic effects comparable to diclofenac (5 mg/kg) and central analgesic effects similar to morphine (5 mg/kg) in validated experimental models.

Keywords

Ruellia tuberosa; Popping pod; Chemical composition; Acute toxicity; Analgesic activit

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DOI: https://doi.org/10.34238/tnu-jst.12974

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