ANTIDIABETIC EFFECT OF ETHANOLIC LEAF EXTRACT  OF VERNONIA AMYGDALINA DEL. IN MICE

Nguyễn Thị Hồng Hạnh; Đoàn Thanh Hiếu; Trần Thị Hồng

ANTIDIABETIC EFFECT OF ETHANOLIC LEAF EXTRACT OF VERNONIA AMYGDALINA DEL. IN MICE

About this article

Received: 24/12/19 Revised: 10/01/20 Published: 20/01/20

Authors

1. Nguyen Thi Hong Hanh , TNU - University of Medicine and Pharmacy
2. Doan Thanh Hieu, TNU - University of Medicine and Pharmacy
3. Tran Thi Hong, TNU - University of Medicine and Pharmacy

Abstract

Vernonia amygdalina leaves are mostly consumed in Asia and Africa, due to its potential as a good source of antidiabets. This study investigated the antidiabetic activity of the ethanolic leaf extract of Vernonia amygdalina Del. Extract with 100 mg/kg and 200 mg/kg doses were given to both normoglycemic and alloxan-induced diabetic Swiss mice. Blood was withdrawn and tested at 0, 3, 7, 14 and 21 days. Results showed that the extract caused reduction in glycemia in both two doses. The 200 mg/kg dose caused the most significant (p<0.05) reduction in blood sugar (-50.3%) compared to insulin (-52.7%).

Keywords

ethanol extract, Vernonia amygdalina del, Swiss mice, alloxan, insulin

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