Email this article SYNTHESIS OF SOME 2-ARYL-4-(4’-HYDROXY-N-METHYL-2’(1H)-QUINOLONE-3’-YL)-1,5-BENZOTHIAZEPINE FROM N-METHYLANILIN
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Received: 11/09/20 Revised: 13/11/20 Published: 27/11/20Authors
1. Duong Ngoc Toan
, TNU - University of Education2. Le Minh Quy, TNU - University of Education
Abstract
Benzothiazepines with many valuable activities have been paid attention bymany scientists around the world. This paper presents the result of synthesizing some new benzothiazepines from N-methylaniline. α,β-unsaturated ketones intermediates were synthesized by the 3-acetyl-4-hydroxy-1-methylquinolin-2-(1H)-on condensation reaction with aromatic aldehydes. The products were then modified by cyclising condensation reaction with o-aminothiophenol to form a series of new benzothiazepines (4 compounds). The structure of these products has been confirmed by IR, NMR and MS spectroscopy methods.
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