Email this article SURVEYING INSULIN RESISTANCE IN SUBJECTS WITH PREDIABETES DETECTED FOR THE FIRST TIME
About this article
Received: 16/10/20 Revised: 29/10/20 Published: 31/10/20Authors
1. Phan Thanh Nhung
, Thai Nguyen National Hospital2. Nguyen Thu Huong, Thai Nguyen National Hospital
3. Nguyen Minh Tuan, Thai Nguyen Medical College
Abstract
Pre-diabetes is a limited hyperglycemia and a direct risk of type 2 diabetes. To prevent the progression of diabetes, it is necessary to assess insulin resistance and its association with some clinical features of first detected prediabetes. The study was conducted on 117 pre-diabetes people, who were diagnosed according to the standards of the Vietnam Endocrinology - Diabetes Association. Insulin resistance is based on the HOMA2 formula with normal value glucose-insulin pair. Insulin resistance indexes are based on the corresponding reference in the normal person. The results showed that the rate of insulin resistance (HOMA2-IR) was 72.6%, decreased insulin sensitivity (HOMA2-%S) was 53.8% and decreased beta cell function (HOMA2-b) was 37.6%. The insulin resistance index (HOMA2-IR) increases with age, obesity, lipid disorders, but not related to gender, waist circumference, hypertension and metabolic syndrome.
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[1]. N.V.V. Hau, and N. H. Thuy, “Rediction of type 2 diabetes mellitus by FINDRISC on pre-diabetes patients over 45 years old,” Journal of Medicine and Pharmacy - Hue University of Medicine and Pharmacy, no. 10, pp. 20-29, 2012.
[2]. S. Akter, M. M. Rahman, and S. K. Abe, “Prevalence of diabetes and prediabetes and their risk factors among Bangladeshi adults: a nationwide survey,” Bull World Health Organ, vol. 92, no. 3, pp. 204-213, 2014.
[3]. P. V Doan, “Research on the risk factors, insulin resistance index and the outcome of intervention therapy in persons with pre-diabetes”, Medical doctoral thesis, Military Medical University, 2018.
[4]. National Diabetes Information Clearinghouse, Insulin Resistance and Prediabetes, NIH Publication, no. 14-4893, June 2014.
[5]. V. Sales, and M. E. Patti, “The Ups and Downs of Insulin Resistance and Type 2 Diabetes: Lessons from Genomic Analyses in Humans,” Curr Cardiovasc Risk Rep. vol. 7, no. 1, pp. 46-59, 2013.
[6]. A. G. Tabák, C. Herder, and W. Rathmann, “Prediabetes: a high-risk state for diabetes development,” Lancet, vol. 379, no. 9833, pp. 2279-2290, 2012.
[7]. T. Phillip, “Prediabetes and Lifestyle Modification: Timeto Prevent a Preventable Disease,” The Permanente Journal, vol. 18 no. 3, pp. 88-93, 2014.
[8]. G. Yang, C. Li, and Y. Gong, “Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose sTolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research),” Journal of Diabetes Research, vol. 2016, 2016, article ID 9270768, doi: 10.1155/2016/9270768.Refbacks
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