CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF EXTRACTS FROM THE AERIAL PARTS OF GLYCOSMIS PARVIFLORA (SIMS) LITTLE

Nguyễn Đình Quỳnh Phú; Nguyễn Khánh Thùy Linh; Đoàn Thị Ái Nghĩa; Tống Văn Dự; Nguyễn Thị Thu Thùy

doi:10.34238/tnu-jst.4615

CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF EXTRACTS FROM THE AERIAL PARTS OF GLYCOSMIS PARVIFLORA (SIMS) LITTLE

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Received: 09/06/21 Revised: 27/10/21 Published: 29/10/21

Authors

1. Nguyen Dinh Quynh Phu, University of Medicine and Pharmacy - Hue University
2. Nguyen Khanh Thuy Linh , University of Medicine and Pharmacy - Hue University
3. Doan Thi ai Nghia, University of Medicine and Pharmacy - Hue University
4. Tong Van Du, University of Medicine and Pharmacy - Hue University
5. Nguyen Thi Thu Thuy, University of Medicine and Pharmacy - Hue University

Abstract

Glycosmis parviflora (Sims) Little is used in traditional Vietnamese medicine to treat cold, cough, indigestion… Studies on the chemical components and biological activities of this species are few. The objective of the present study was to determine the total phenolic contents (TPC), total flavonoid contents (TFC), and to evaluate the antioxidant potential of methanolic crude extract and partition extracts of the aboveground part of Glycosmis parviflora (Sims) Little. Total phenolic contents, total flavonoid contents and antioxidant activities were determined by spectrophotometry method, using reagents of Folin-Ciocalteu, AlCl₃ and a solution of 1,1-diphenyl-2-picrylhydrazyl (DPPH) in methanol, respectively. TPC were highest in ethyl acetate extract (147.47 ± 0.33mg GAE/g extract); TFC were highest in n-hexane extract (132.71 ± 0.14mg QE/g extract); the antioxidant activity of ethyl acetate extract was strongest with IC₅₀ = 36.36 ± 0.10 μg/mL and n-hexane extract was weakest with IC₅₀ = 416.65 ± 0.18 μg/mL. Ethyl acetate extract and n-hexane extract achieved the highest TPC and TFC, respectively. Ethyl acetate extract reached the maximum value of both TPC and the antioxidant potential.

Keywords

Total phenolic contents; Total flavonoid contents; DPPH; Glycosmis parviflora; Ethyl acetate extract

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References

[1] F. Pourmorad, S. J. Hosseinimehr, and N. Shahabimajd, “Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants,” Afr. J. Biotechnol, vol. 5, pp. 1142-1145, 2006.

[2] S. P. Wong, L. P. Leong, and J. H. W. Koh, “Antioxidant activities of aqueous extracts of selected plants,” Food Chem., vol. 99, pp. 775-783, 2006.

[3] L. Su, J.-J. Yin, D. Charles, K. Zhou, J. Moore, and L. Yu, “Total phenolic contents, chelating capacities, and radical-scavenging properties of black peppercorn, nutmeg, rosehip, cinnamon and oregano leaf,” Food Chem., vol. 100, pp. 990-997, 2007.

[4] B. Tepe, O. Eminagaoglu, H. A. Akpulat, and E. Aydin, “Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia verticillata (L.) subsp. verticillata and S. verticillata (L.) subsp. amasiaca (Freyn & Bornm.) Bornm.,” Food Chem., vol. 100, pp. 985-989, 2007.

[5] T. Ghosh, K. T. Maity, P. Sengupta, K. D. Dash, and A. Bose, “Antidiabetic and in vivo antioxidant activity of ethanolic extract of Bacopa monnieri Linn. aerial parts: a possible mechanism of action,” Iranian J. Pharm. Res, vol. 7, pp. 61-68, 2008.

[6] B. I. Ognjanovic, S. D. Markovic, S. Z. Pavlovic, R. V. Zikic, A. S. Stajn, and Z. S. Saicic, “Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: protective effect of selenium,” Physiol. Res, vol. 57, pp. 403-411, 2008.

[7] C. J. Dillard and J. B. German, “Phytochemicals: nutraceuticals and human health,” J. Sci. Food Agric., vol. 80, pp. 1744-1756, 2000.

[8] A. Turkoglu, M. E. Duru, N. Mercan, I. Kivrak, and K. Gezer, “Antioxidant and antimicrobial activities of Laetiporus sulphureus (Bull.) Murrill.,” Food Chem., vol. 101, pp. 267-273, 2007.

[9] J. M. Canadanovic-Brunet, S. M. Djilas, G. S. Cetkovic, and V. T. Tumbas, “Free-radical scavenging activity of wormwood (Artemisia absinthium L.) extracts,” J. Sci. Food Agric., vol. 85, pp. 265-272, 2005.

[10] A. Rohman, S. Riyanto, N. Yaniarti, W. R. Saputra, and R. Utami, “Antioxidant activity, total phenolic, and total flavonoid of extracts and fractions of red fruit (Pandanus conoideus Lam),” Int. Food Res. J, vol. 17, pp. 97-106, 2010.

[11] O. Caliskan and A. A. Polat, “Phytochemical and antioxidant properties of selected fig (Ficus carica L.) accessions from the eastern Mediterranean region of Turkey,” Scientia Horticulturae, vol. 128, no. 4, pp. 473-478, 2011.

[12] P. K. Verma, R. Raina, S. P. Singh, and M. Sultana, “Oxidative stress: pharmacology of vitamin E,” Journal of veterinary Pharmacology & toxicology, vol. 10, no. (1-2), pp. 1-7, 2011.

[13] P. H. Ho, An Illustrated Flora of Vietnam, vol. 2, pp. 952, Tre Publishing House (In Vietnamese), 2003.

[14] Z. L. Liu, K. Yang, P. H. Bai et al., “Gas chromatography-mass spectrometric analysis of essential oil of aerial parts of Glycosmis parviflora (Sims) Little (Rutaceae),” Tropical Journal of Pharmaceutical Research, vol. 13, no. 2, pp. 275-280, 2014.

[15] Y. Mohammad, K. T. Manish, S. Pushpendra, and S. Rahul, “The Genus Glycosmis [Rutaceae]: A Comprehensive Review on its Phytochemical and Pharmacological Perspectives,” The Natural Products Journal, vol. 9, no. 2, pp. 98-124, 2019.

[16] S. Xiaoling, Z. Huifang, C. Zhen, and Z. Guanghua, “Study on chemical constituents isolated from Glycosmis citrifolia,” Zhongguo yao xue za zhi (Zhongguo yao xue hui : 1989), vol. 37, no. 1, pp. 14-17, 2002.

[17] Y. L. Leu, Y. Y. Chan, T. S. Wu, C. M. Teng, and K. T. Chen, “Antiplatelet aggregation principles from Glycosmis citrifolia,” Phytotherapy Research, vol. 12, pp. 1997-1999, 1998.

[18] M. Rahmani, R. M. Serang, N. M. Hashim et al., “Alkaloids and sulphur-containing amides from Glycosmis citrifolia and Glycosmis elongata,” Sains Malaysiana, vol. 39, no. 3, pp. 445-451, 2010.

[19] International standard (ISO 14502-1), “Determination of substances characteristic of green and black tea – Part 1: content of total polyphenols in tea - Colorimetric method using Folin-Ciocalteu reagent,” First edition, 2005.

[20] A. Pekal and K. Pyrzynska, “Evaluation of aluminium complexation reaction for flavonoid content assay,” Food Analytical Methods, vol. 7, no. 9, pp. 1776-1782, 2014.

[21] O. T. Asekun, S. O. Okoh, O. B. Familoni, and A. J. Afolayan, “Chemical profiles and antioxidant activity of essential oils extracted from the leaf and stem of Parkia biglobosa (Jacq) Benth,” Research Journal of Medicinal plant, vol. 7, no. 2, pp. 82-91, 2013.

[22] S. M. Hossain, I. Farhana, S. Tasnuva et al., "In vitro antioxidant, membrane stabilizing and thrombolytic activities of Glycosmis arborea," Bangladesh Pharmaceutical Journal, vol. 15, no. 2, pp. 141-143, 2012.

[23] I. J. Bulbul and N. Jahan, "Study on antioxidant and antimicrobial activities of methanolic leaf extract of Glycosmis pentaphylla against various microbial strains," Journal of Pharmacognosy and Phytochemistry, vol. 5, no. 4, p. 53, 2016.

[24] M. Yasir, P. Singh, M. K. Tripathi et al., “Antioxidant and antifungal activity of Glycosmis pentaphylla roots against dermatophytes and yeast-like fungi responsible for various skin ailments,” Oxid Commun, vol. 38, no. 4, pp. 1622-1631, 2015.

[25] K. Ali, A. W. Meredith, and H. R. Thomas, “Techniques for analysis of plant phenolic compounds,” Molecules, vol. 18, no. 2, pp. 2328-2375, 2013.

[26] M. A. Howlader, F. Rizwan, S. Sultana et al., "Antimicrobial, antioxidant and cytotoxic effects of methanolic extracts of leaves and stems of Glycosmis pentaphylla (Retz.)," Journal of Applied Pharmaceutical Science, vol. 1, no. 8, pp. 137-140, 2011.

[27] N. Gupta, M. Agarwal, V. Bhatia, S. K. Jha, and J. Dinesh, “In vitro antioxidant activity of crude extracts of the plant Glycosmis pentaphylla correa,” International Journal of Pharmaceutical Sciences Review and Research, vol. 6, no. 2, pp. 159 -162, 2011.

DOI: https://doi.org/10.34238/tnu-jst.4615

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