STUDY TO DEVELOP FORMULA AND PREPARATION PROCESS OF GRANULES FROM THE TRADITIONAL REMEDY “KHA TU CAM CAT THANG”

Đoàn Thị Trà My; Nguyễn Tấn Khanh; Đặng Thị Yến Nhi; Trần Thị Thùy Linh

doi:10.34238/tnu-jst.5103

STUDY TO DEVELOP FORMULA AND PREPARATION PROCESS OF GRANULES FROM THE TRADITIONAL REMEDY “KHA TU CAM CAT THANG”

About this article

Received: 01/10/21 Revised: 25/10/21 Published: 26/10/21

Authors

1. Doan Thi Tra My, University of Medicine and Pharmacy - Hue University
2. Nguyen Tan Khanh, Dong A University
3. Dang Thi Yen Nhi, University of Medicine and Pharmacy - Hue University
4. Tran Thi Thuy Linh , University of Medicine and Pharmacy - Hue University

Abstract

The remedy “Kha tu cam cat thang” consists of 3 medicinal plants: Chinese licorice, Balloon flower root and Chebulic myrobalan fruit, which support lung qi to descend, suppress cough, nourish the throat area, tonify the yin, hence it can treat cough due to cold, hoarseness and loss of voice. Conduct surveys on temperature, time and excipients factors to develop formula and preparation process of granules. Wet granule sieving method has been used. Prepare a concentrated extract of the medicinal herbs for the traditional remedy “Kha tu cam cat thang” by hot water extraction method, at a 1:8 (g/ml) plants : solvent ratio, extracted once in 2 hours at 100ºC. Take 15 g of the concentrated extract to incorporate with excipients including lactose (80.3 g), aspartame (0.4 g) and vanillin (0.3 g), thus form a dual powder. Followed by adding PVP binder 10% and blending well to create a damp mass, then proceed to sift granules through a sieve to obtain final products. The study has developed the formula and the preparation process for granular preparation of the remedy “Kha tu cam cat thang” in the treatment of cough.

Keywords

Kha tu cam cat thang; Cough; Granules; Granular preparation; Formula

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References

[1] A. B. Goldsobel and B. E. Chipps, "Cough in the pediatric population," Journal of Pediatrics, vol. 156, no. 3, pp. 352-358, 2010.

[2] K. F. Chung and J. G. Widdicombe, "Pharmacology and therapeutics of cough. Preface," Handbook of Experimental Pharmacology, no. 187, pp. v-vi, 2009.

[3] S. M. Schappert and C. W. Burt, "Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001-02," Vital and health statistics. Series 13, no. 159, pp. 1-66, 2006.

[4] Z. Hai-long, C. Shimin, and L. Yalan, "Some Chinese folk prescriptions for wind-cold type common cold," Journal of Traditional and Complementary Medicine, vol. 5, no. 3, pp. 135-137, 2015.

[5] S. Sultana, A. Khan, M. Safhi, and H. Alhazmi, "Cough Suppressant Herbal Drugs: A Review," International Journal of Pharmaceutical Science Invention, vol. 5, no. 5, pp. 15-28, 2016.

[6] L. Wagner et al., "Herbal Medicine for Cough: a Systematic Review and Meta-Analysis," Forschende Komplementarmedizin (2006), vol. 22, no. 6, pp. 359-368, 2015.

[7] H. D. Tan and T. V. Nhu, Dictionary of traditional medicine. Dong Nai Publishing House (in Vietnamese), 2011.

[8] Ministry of health, Pharmacognosy (part I). Hanoi: Medical Publishing House (in Vietnamese), 2011.

[9] P. X. Sinh, Traditional Medicine. Hanoi: Medical Publishing House (in Vietnamese), 2018.

[10] National Institute of Medicinal Materials, Plants and animals in traditional medicine in Vietnam (part I). Hanoi: Science and technics publishing house (in Vietnamese), 2006.

[11] M.-Y. Ji et al., "The Pharmacological Effects and Health Benefits of Platycodon grandiflorus-A Medicine Food Homology Species," Foods, vol. 9, p. 142, 2020.

[12] L. Zhang et al., "Platycodon grandiflorus - an ethnopharmacological, phytochemical and pharmacological review," Journal of ethnopharmacology, vol. 164, pp. 147-161, 2015.

[13] G. Nosalova, L. Jurecek, U. R. Chatterjee, S. K. Majee, S. Nosal, and B. Ray, "Antitussive Activity of the Water-Extracted Carbohydrate Polymer from Terminalia chebula on Citric Acid-Induced Cough," Evidence-based complementary and alternative medicine: eCAM, vol. 2013, pp. 650134-650134, 2013.

[14] V. Badmaev and M. Nowakowski, "Protection of epithelial cells against influenza A virus by a plant derived biological response modifier Ledretan-96," Phytotherapy Research, vol. 14, no. 4, pp. 245-249, 2000.

[15] K. Rai Aneja and R. Joshi, "Evaluation of antimicrobial properties of fruit extracts of Terminalia chebula against dental caries pathogens," Jundishapur Journal of Microbiology, vol. 2, no. 3, pp. 105-111, 2009.

[16] A. Bag, S. K. Bhattacharyya, and R. R. Chattopadhyay, "The development of Terminalia chebula Retz. (Combretaceae) in clinical research," Asian Pac J Trop Biomed, vol. 3, no. 3, pp. 244-252, 2013.

[17] Ministry of health, Vietnamese pharmacopoeia V. Hanoi: Medical Publishing House (in Vietnamese), 2018.

[18] Ministry of health, Pharmaceutics and biopharmacology (part II). Hanoi: Vietnam education publishing house (in Vietnamese), 2010.

[19] Ministry of health, Preparation techniques and biopharmacology (part II). Hanoi: Medical Publishing House (in Vietnamese), 2014.

DOI: https://doi.org/10.34238/tnu-jst.5103

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