IN VITRO ANTIBACTERIAL ACTIVITY OF AMPELOPSIS CANTONIENSIS EXTRACTS CULTIVATED AT DANANG AGAINST CLINICALLY ISOLATED STAPHYLOCOCCUS AUREUS

Ngô Thái Bích Vân; Đào Thị Thu Thảo; Hoàng Thanh Trung; Triệu Tuấn Anh; Võ Dương Nguyên Sa; Kim Văn Hùng; Phạm Trần Vĩnh Phú

doi:10.34238/tnu-jst.5869

IN VITRO ANTIBACTERIAL ACTIVITY OF AMPELOPSIS CANTONIENSIS EXTRACTS CULTIVATED AT DANANG AGAINST CLINICALLY ISOLATED STAPHYLOCOCCUS AUREUS

About this article

Received: 18/04/22 Revised: 20/07/22 Published: 20/07/22

Authors

1. Ngo Thai Bich Van, University of Danang - Danang University of Science and Technology
2. Dao Thi Thu Thao, University of Danang - Danang University of Science and Technology
3. Hoang Thanh Trung, Danang Family Hospital
4. Trieu Tuan Anh, Dong A University - Danang
5. Vo Duong Nguyen Sa, Danang Dermato-Venereology Hospital
6. Kim Van Hung, Danang Dermato-Venereology Hospital
7. Pham Tran Vinh Phu , Dong A University - Danang

Abstract

The Gram-positive Staphylococcus aureus is a common pathogen that causes many serious infectious diseases in humans, especially in hospital settings. Therefore, discovery and development of new antibiotics or new generations of antibiotics to treat infections caused by S. aureus is an urgent issue in Vietnam and all over the world. In this study, we isolated S. aureus from patient sample and investigated the antibacterial potency of Ampelopsis cantoniensis extracts collected in Da Nang. The results showed that ethanolic crude extract can suppress in vitro growth of this strain after 24 hours. The ethylacetate fraction has the highest inhibitory effect on the growth of S.aureus bacteria, with minimum inhibitory concentration (MIC) of 0,1 mg/ml and minimum bactericidal concentration (MBC) of 0,4 mg/ml. Whereas, extract of n-hexane fraction does not show antibacterial activity against S. aureus. These initial results are the premise for further studies on the antibacterial mechanism of Ampelopsis cantoniensis in the future.

Keywords

Staphylococcus aureus; Extracts; Ampelopsis cantoniensis; Antimicrobial activity; MIC

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DOI: https://doi.org/10.34238/tnu-jst.5869

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