EVALUATION OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF EXCOECARIA COCHINCHINENSIS L. IN TUYEN QUANG PROVINCE

Lành Thị Ngọc; Trần Thị Thanh Vân; Nguyễn Kiều Linh; Đàm Thị Bích Hạnh

doi:10.34238/tnu-jst.6127

EVALUATION OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF EXCOECARIA COCHINCHINENSIS L. IN TUYEN QUANG PROVINCE

About this article

Received: 07/06/22 Revised: 04/11/22 Published: 24/11/22

Authors

1. Lanh Thi Ngoc, TNU - University of Agriculture and Forestry
2. Tran Thi Thanh Van , Tan Trao University
3. Nguyen Kieu Linh, Tan Trao University
4. Dam Thi Bich Hanh, Tay Nguyen University

Abstract

This study evaluated the antibacterial and antioxidant activities of the crude extract (EC); fractional extracts: n-hexane (ECH), ethyl acetate (ECE) and methanol (ECM) from the leaves of Excoecaria cochinchinensis in Tuyen Quang. The following results: Crude extract (EC) inhibited the growth of 4 strains of bacteria and fungi Bacillus subtillis, Staphylococcus aureus, Fusarium oxysporum and Saccharomyces cerevisiae; n-hexane (ECH) inhibited the growth of 3 strains of Bacillus subtillis, Staphylococcus aureus and Saccharomyces cerevisiae; High ethyl acetate (ECE) exhibited activity against strains of Bacillus subtillis, Staphylococcus aureus, Fusarium oxysporum and Saccharomyces cerevisiae; and high methanol (ECM) of red monocarpus plants resistant to Escherichia coli and Bacillus subtillis strains were all with MIC values of 200 mg/ml. Crude extract (EC) represents the ability to neutralize free radicals SC 65.44 ± 1.2%, corresponding to SC₅₀ value of 50.32 µg/mL. In the high-fraction extracts ECE exhibited the best antioxidant activity with DPPH assay with free radical neutralization ability SC 72.18 ± 1.1%, corresponding to SC₅₀value of 50.32 µg/mL. This research has contributed to supplement and improve the medicinal value of this precious medicinal plant.

Keywords

Excoecaria cochinchinensis; Antimicrobial; Antioxidant; SC50 value; MIC value

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References

[1] Ministry of Health, Fifth Vietnam Pharmacopoeia. Medicine Publishing House, p. 786, 2017.

[2] H. B. Do et al., Medicinal plants and medicinal animals in Vietnam, vol. 1 Natural Science and Technology Publishing House, pp. 555-556, 2006.

[3] M. G. Phan, T. S. Phan, K. Matsunami, and H. Otsuka, "New Megastigmane Glucosides from Excoecaria cochinchinensis LOUR. var. cochinchinensis,” Chemical and Pharmaceutical Bulletin, vol. 53, no. 12, pp. 1600-1603, 2005.

[4] Y.-L. Wang, P. Li, K.-J. Guo, L.-Y. Chen, and Q. Tong, “Isolation and identification of chemical constituents of Excoecaria cochinchinensis Lour,” Nat. Prod. Res, vol. 26, pp. 47-49, 2014.

[5] C.V.Vo, Dictionary of Vietnamese medicinal plants, Medical Publishing House, vol. 1, pp 767, 2012.

[6] N. T. An, P. X. Sinh, C. V. Thư, and N. T. A. Thư, “Preliminary exploration of some biological effects of red monsoli leaves,” Journal of Medicinal Materials, vol. 4, pp. 20-21, 1999.

[7] N. T. An and P. X. Sinh, “Preliminary research on chemical composition of medicinal herbs Excoecaria cochinchinensis Lour.,” Journal of Medicinal Medicinal vol. 4, p. 9, 1999.

[8] T. A. Nguyen and X. X. Pham, “Study on chemical composition and biological effects of red monocot leaves,” Journal of Medicinal Plants, vol. 7, no. 2, pp. 35-37, 2002.

[9] H. H. Lai, P. T. Nguyen, H. A. Do, T. H. H. Tran, D. C. Nguyen, T. C. Nguyen, V. T. Nguyen, X. C. Nguyen, H. N. Nguyen, D. Q. Ngo, and V. M. Chau, “Metabolites from Excoecaria cochinchinensis Lour,” Phytochemistry Letters, vol. 37, pp. 116-120, 2020.

[10] S. Zaetun and L. Srigede, “The Determination of Haemostasis Value in Relation to Potential Blood Leaf Leaves Filtrate (Excoecaria cochinchinensis L) as the External Medicine for Skin Wound of White Rat (Rattus norvegicus),” Indonesian Journal of Medicine, vol. 5, no. 1, pp. 10-16, 2020.

[11] P. Leelapornpisid, S. Chansakao, T. Ittiwittayawat, and S. Pruksakorn, “Antimicrobial activity of herbal extracts on staphylococcus aureus and propionibacterium acnes,” III Wocmap Congress on Medicinal and Aromatic Plants, vol. 5, pp. 97-104, 2005.

[12] L. Kui,Q. Kong,X. Yang,Y. Pan,Z. Xu,S. Wang,J. Chen,K. Wei,X. Zhou,X. Yang,T. Wu, A. Mastan,Y. Liu, and J. Miao, “High-Throughput In Vitro Gene Expression Profile to Screen of Natural Herbals for Breast Cancer Treatment,” Front Oncol., vol. 11, 2021, Art. no. 684351.

[13] H. Luo, W. Li, X. Zhang, S. Deng, Q. Xu, T. Hou, X. Pang, Z. Zhang, and X. Zhang, “In planta high levels of hydrolysable tannins inhibit peroxidase mediated anthocyanin degradation and maintain abaxially red leaves of Excoecaria Cochinchinensis,” BMC Plant Biology, vol. 19, p. 315, 2019.

[14] K. Ymada, S. K. Nabeta, M. Yamasaki, K. Katakura, and H. Matsuura, “Isolation of Antibabesial Compounds from Brucea javanica, Curcuma xanthorrhiza and Excoecaria cochinchinensis,” Bioscience, Biotechnology, and Biochemistry, vol. 73, no. 3, pp. 776-780, 2019.

DOI: https://doi.org/10.34238/tnu-jst.6127

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