THE CLINICAL, PARACLINICAL FEATURES AND OUTCOMES IN CHILDREN WITH CORTICOSTEROID RESISTANT NEPHROTIC SYNDROME AT BAC NINH CHILDREN HOSPITAL

Abstract

This study describes the clinical, paraclinical features and outcomes in children with corticosteroid-resistant nephrotic syndrome at Bac Ninh Children's Hospital. Description prospective was studied  on 37 children with Corticosteroid-resistant nephrotic syndrome, hospitalized in the Bac Ninh Children's Hospital from 1/2021 to 12/2021. The results revealed that, in 37 examined children, there were 27/37 (73%) male, and 10/37 (27%) female, rate of male/female were 2.7/1. The median age was 10.1±3.3 years old. The clinical condition was characterized by 54.1% (20/37) of Simple nephrotic syndrome, and 94.6% (35/37) of Primary nephrotic syndrome. Patients often had 100% with edema of various degrees of which 27.1% (10/37) had severe edema, and 6/37 (16.2%) had hypertension. Paraclinical features were 28/37 (75.7%) increased white blood cell count, 100% hypoalbuminemia, 36/37 (97.3%) decreased plasma proteins, 02/37 (5.4%) anemia and increased blood urea, Creatinine concentrations increased was 01/37 (2.7%). As a result of treatment, the degree of edema decreased gradually over time of treatment, after 6 months, and 12 months (all over 90%). The mean time for proteinuria to return negative was 1.76 ± 0.99 months. There was a gradual decrease in the number of leukocytes back to the normal limit over the course of treatment and there was a significant decrease in blood urea after 12 months of treatment compared to after 6 months (p<0.05), the ratio Overall treatment outcome rate is 21/37 (56.8%) good. Characteristic clinical and subclinical manifestations of pediatric patients with severe corticosteroid-resistant nephrotic syndrome, the proportion of complete remissions was degree median.