CLINICAL, ENDOSCOPIC AND HISTOLOGICAL FEATURES OF   PATIENTS WITH GASTRIC ADENOCARCINOMA IN THE ANTRUM

Trần Ngọc Thụy; Nguyễn Phú Hùng; Dương Hồng Thái

doi:10.34238/tnu-jst.6290

CLINICAL, ENDOSCOPIC AND HISTOLOGICAL FEATURES OF PATIENTS WITH GASTRIC ADENOCARCINOMA IN THE ANTRUM

About this article

Received: 24/07/22 Revised: 26/09/22 Published: 07/10/22

Authors

1. Tran Ngoc Thuy , TNU - University of Medicine and Pharmacy
2. Nguyen Phu Hung, TNU - University of Sciences
3. Duong Hong Thai, TNU - University of Medicine and Pharmacy

Abstract

This study describes some clinical features, macroscopic images and histopathological characteristics of gastric adenocarcinoma tumors. The study subjects included 150 cases of gastric adenocarcinoma operated at Hanoi K hospital using a cross-sectional descriptive study method. The results revealed that the rate of stomach cancer is highest in the age group 60-69, male/female ratio: 1.94/1. The most common systemic and functional symptoms were epigastric pain (99.3%). Ulcerative lession was 53.3%, followed by polypoid (36%), polyps (2.7%), and infiltrates (8%). According to Lauren classification, intestinal type accounted for 72.7%, diffuse type was 22.7% and mixed type was 4.7%. According to WHO, 58.7% of cases are tubular adenocarcinoma, signet ring cell carcinoma was 22.7%, mucinous adenocarcinoma was 12%, mixed carcinoma was 4.7% and papillary adenocarcinoma was 2%. In terms of differentiation, 19.3% of cases was well differentiated, moderately differentiated was 37.3%, and poorly differentiated was 43.3%. All most patients (98.7%) were diagnosed and undergoing surgery at an advanced stage (stage II to stage IV).

Keywords

Gastric adenocarcinoma; Endoscopy; Tubular adenocarcinoma; Signet ring cell carcinoma; Mucinous adenocarcinoma

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References

[1] H. Sung, J. Ferlay, and R. L. Siegel, "Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries," CA Cancer J Clin, vol. 71, no. 3, pp. 209-249, 2021.

[2] International Agency for Research on Cancer (IARC), “Global Cancer Observatory — Vietnam Population fact sheets,” 2020. [Online]. Available: http://gco.iarc.fr/today/data/factsheets/populations/ 704-viet-nam-fact-sheets.pdf. [Accessed Oct. 26, 2020].

[3] V. N. Le, “Studying the expression of egfr, her2 and their relationship with clinical, endoscopic, histopathological characteristics in patients with gastric adenocarcinoma,” Doctoral thesis, Hue University Medicine and Pharmacy, Hue, 2014.

[4] D. Kohoutova and M. Banks, “Advances in the Aetiology & Endoscopic Detection and Management of Early Gastric Cancer,” Cancers (Basel), vol. 13, no. 24, p. 6242, 2021.

[5] M. Dobrițoiu, A. E. Stepan, C. C. Vere, and C. E. Simionescu, "Evaluation of Gastric Carcinomas Histological Patterns in Relation to Tumors Aggressiveness Parameters,” Curr Health Sci J, vol. 44, no. 4, pp. 342-346, 2018.

[6] J. Machlowska and J. Baj, “Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies,” Int J Mol Sci, vol. 21, no. 11, p. 4012, 2020.

[7] N. H. Nguyen, V. T. Nguyen, and V. B. Nguyen, "Histopathological classification of gastric cancer," Medicine Ho Chi Minh City, vol. 1, no. 3, pp. 57-60, 2007.

[8] H. J. Wanebo, B. J. Kennedy, J. Chmiel, G. Steele, D. Winchester, and R. Osteen, "Cancer of the stomach. A patient care study by the American College of Surgeons," Ann Surg, vol. 218, no. 5, pp. 583-592, 1993.

[9] X. K. Nguyen, “Anatomic pathology and prognosis of early gastric cancer,” Vietnamese Journal of Gastroenterology, vol. 4, no. 16, pp. 1057-1060, 2009.

[10] D. Lazăr, S. Tăban, I. Sporea, A. Dema, M. Cornianu, and E. Lazăr, "Gastric cancer: correlation between clinicopathological factors and survival of patients (III)," Rom J Morphol Embryol, vol. 50, no. 3, pp. 369-379, 2009.

[11] K. E. Lee, H. J. Lee, Y. H. Kim, H. J. Yu, H. K. Yang, and W. H. Kim, "Prognostic significance of p53, nm23, PCNA and c-erbB-2 in gastric cancer," Jpn J Clin Oncol, vol. 33, no. 4, pp. 173-179, 2003.

DOI: https://doi.org/10.34238/tnu-jst.6290

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