EFFECT OF MUI MAC IN MOUSE LIVER INJURY INDUCED BY PARACETAMOL

Abstract

Effect of Mui mac was studied on acute liver injury induced by single dose of paracetamol 400 mg/kg, po, in mice. Activity was monitored by estimating the serum transaminases (ALT and AST), MDA content in liver homogenates, and by histopathological changes in the livers of experimental mice. The results showed that segment ethylacetate and total extraction of Mui mac with dose of 9.6 grs/kg per day and 28.8 grs/kg per day reduced in the level of serum ALT, AST and ameliorated paracetamol-induced histopathological changes in the livers of experimental mice. The results suggest that Mui mac has acceleratedofliver injury recover against paracetamol intoxication in mice.