COMPARATIVE ASSESSMENT OF ANTIBACTERIAL AND  ANTIFUNGAL ACTIVITIES OF METALLIC ION BASED FORMULATIONS

Nguyễn Thị Kiều Oanh; Nghiêm Thị Hà Liên; Nguyễn Hà Nhung; Đặng Khánh Phương

doi:10.34238/tnu-jst.7341

COMPARATIVE ASSESSMENT OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF METALLIC ION BASED FORMULATIONS

About this article

Received: 15/02/23 Revised: 16/05/23 Published: 16/05/23

Authors

1. Nguyen Thi Kieu Oanh , University of Science and Technology of Hanoi - VAST
2. Nghiem Thi Ha Lien, Institute of Physics - VAST
3. Nguyen Ha Nhung, University of Science and Technology of Hanoi - VAST
4. Dang Khanh Phuong, University of Science and Technology of Hanoi - VAST

Abstract

The threat posed by antibiotic resistance has become particularly critical in recent years because multiple and extended resistant bacteria have become more prevalent, leading to more common hard-to-treat infections worldwide. There is an urgent need to develop new antimicrobial agents against drug-resistant strains. The present study aims to investigate the potential of the new formulations including silver (I) nanoparticles as well as copper (II) and zinc (II) chelates in their separated and complex forms in the treatment of infectious diseases. The capacity of metallic ion based systems to suppress the development of microorganism often seen on wounds, such as Gram-negative bacteria (Klebsiella pneumonia ATCC 700603, Pseudomonas aeruginosa ATCC 27853), Gram-positive bacteria (Staphylococcus aureus ATCC 29213), and fungi (Candida albicans ATCC 10231) were evaluated by microdilution assay. We showed the inhibition percentage against each bacterial strain, which can be used to calculate the minimum inhibitory concentration (MIC) of these metal ions formulations. The positive results suggested that these formulas thus could be developed for wound care in therapy.

Keywords

Antibacterial activity; Antifungal activity; Copper (II) chelates; Silver(I) nanoparticles; Zinc (II) chelates

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References

[1] J. A. Lemire, J. J. Harrison, and R. J. Turner, “Antimicrobial activity of metals: mechanisms, molecular targets and applications,” Nature Reviews Microbiology, vol. 11, no. 6, pp. 371-384, 2013.

[2] K. J. Waldron and N. J. Robinson, “How do bacterial cells ensure that metalloproteins get the correct metal?,” Nature Reviews Microbiology, vol. 7, no. 1, pp. 25-35, 2009.

[3] A. Król, P. Pomastowski, K. Rafińska, V. Railean-Plugaru, and B. Buszewski, “Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism,” Advances in Colloid and Interface Science, vol. 249, pp. 37-52, 2017.

[4] K. Singh, “Antibacterial Co(II), Ni(II), Cu (II) and Zn (II) Complexes of Schiff bases Derived from Fluorobenzaldehyde and Triazoles,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 21, no. 5, pp. 557-562, 2006.

[5] A. Parra, M. Toro, R. Jacob, P. Navarrete, M. Troncoso, G. Figueroa, and A. Reyes-Jara, “Antimicrobial effect of copper surfaces on bacteria isolated from poultry meat,” Brazilian Journal of Microbiology, vol. 49, no. 1, pp. 113-118, 2018.

[6] T. N. Nguyen, Q. H. Do, T. T. D. Vu, T. T. Nguyen, D. T. Nguyen, T. B. N. Nguyen, T. T. H. Tran, T. K. O. Vu, T. H. L. Nghiem, T. M. T. Hoa, T. M. H. Nguyen, P. N. Bui, M. H. Nguyen, M. D. Pham, and T. C. T. Tran, “Enhancement of antibacterial activity by a copper(II) and zinc(II) in chelation with ethylenediaminetetra-acetic acid and urea complex,” Chemistry Papers, vol. 76, pp. 7163-7176, 2022.

[7] F. Amaro, Á. Morón, S. Díaz, A. Martín-González, and J. C. Gutiérrez, “Metallic nanoparticles—friends or foes in the battle against antibiotic-resistant bacteria?,” Microorganisms, vol. 9, no. 2, p. 364, 2021.

[8] L. S. Reddy, M. M. Nisha, M. Joice, and P. Shilpa, “Antimicrobial activity of zinc oxide (ZnO) nanoparticle against Klebsiella pneumoniae,” Pharmaceutical Biology, vol. 52, no. 11, pp. 1388-1397, 2014.

[9] R. K. Sharma and R. Ghose, “Synthesis of zinc oxide nanoparticles by homogeneous precipitation method and its application in antifungal activity against Candida albicans,” Ceramics International, vol. 41, no. 1, pp. 967-975, 2015.

[10] Y. N. Slavin, J. Asnis, U. O. Häfeli, and H. Bach, “Metal nanoparticles: understanding the mechanisms behind antibacterial activity,” Journal of Nanobiotechnology, vol. 15, no. 1, pp. 1-20, 2017.

[11] M. S. Butler, M. A. T. Blaskovich, and M. A. Cooper, “Antibiotics in the clinical pipeline at the end of 2015,” The Journal of Antibiotics, vol. 70, pp. 3-24, 2016.

DOI: https://doi.org/10.34238/tnu-jst.7341

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