ISOLATION AND BIOACTIVE ASSAY OF γ-ORYZANOL  FROM RICE BRAN (ORYZA SATIVA)

Nguyễn Thành Chung; Lưu Đức Huy; Hồ Văn Khánh; Hoàng Quốc Việt; Nguyễn Phương Thảo; Đỗ Bích Hòa; Dương Ngọc Tú

doi:10.34238/tnu-jst.7466

ISOLATION AND BIOACTIVE ASSAY OF γ-ORYZANOL FROM RICE BRAN (ORYZA SATIVA)

About this article

Received: 01/03/23 Revised: 05/03/24 Published: 06/03/24

Authors

1. Nguyen Thanh Chung, Institute of Biological and Food technology – Hanoi Open University
2. Luu Duc Huy, Institute of Chemistry – Vietnam Academy of Science and Technology
3. Ho Van Khanh, Institute of Chemistry – Vietnam Academy of Science and Technology
4. Hoang Quoc Viet, Institute of Chemistry – Vietnam Academy of Science and Technology
5. Nguyen Phuong Thao, Institute of Chemistry – Vietnam Academy of Science and Technology
6. Do Bich Hoa, Institute of Chemistry – Vietnam Academy of Science and Technology
7. Duong Ngoc Tu , Institute of Chemistry – Vietnam Academy of Science and Technology

Abstract

Vietnam is currently the second-largest exporter of rice in the world. Rice bran is a by-product of the milling process. It makes up 14% of the paddy rice seed weight. In the past, rice bran was only used as feed for livestock. This gives very low economic value. Recently, a little amount of rice bran is used in cosmetics and food by using whole bran or bran oil. For improving the value and application of rice bran, we study the composition of rice bran of Thai Binh rice variety. Rice bran oil was extracted by using ethyl acetate extract. From that, a γ-oryzanol compound, 24-methylenecycloartanyl ferulate (CG55), was successfully isolated. Its structure was elucidated by mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compound CG55 showed strong inhibition of enzyme α-glucosidase with IC50 at 5.03 µg/mL, weak antioxidant, and nontoxicity.

Keywords

Rice bran oil; γ-oryzanol; 24- methylenecycloartanyl ferulate; α-glucosidase inhibitor; Antioxidant

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DOI: https://doi.org/10.34238/tnu-jst.7466

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