EVALUATION OF THE RESULTS OF IN VITRO FERTILIZATION IN PATIENTS' OVARIAN STIMULATION BY USING CORIFOLLITROPIN ALFA

Nguyễn Xuân Thành; Nguyễn Xuân Hợi

doi:10.34238/tnu-jst.9175

EVALUATION OF THE RESULTS OF IN VITRO FERTILIZATION IN PATIENTS' OVARIAN STIMULATION BY USING CORIFOLLITROPIN ALFA

About this article

Received: 09/11/23 Revised: 25/03/24 Published: 03/04/24

Authors

1. Nguyen Xuan Thanh , National Hospital of Obstetrics and Gynecology
2. Nguyen Xuan Hoi, National Hospital of Obstetrics and Gynecology

Abstract

The study evaluates the results of in vitro fertilization in patients with ovarian stimulation by using Corifollitropin alfa. Using the cross-sectional descriptive research method, we studied 121 patients indicated for IVF who received egg stimulation with corifollitropin alfa at the National Obstetrics and Gynecology Hospital from 2016 to 2018. Research results show that mean age was 29.63±3.93, with a period of infertility of nearly four years. Embryogenesis results when ovarian stimulation with Corifollitropin alfa was high: the number of embryos was 9.75 ± 4.63 embryos; the average number of good embryos was 7.38±4.37; the average number of frozen embryos was 5.91±4.10 embryos; the average number of embryos transferred was 3.12±0.65 embryos. The proportion of clinical pregnancy and live birth in the first embryo transfer were 31.4% and 19.0%, respectively. In vitro fertilization with Corifollitropin alfa was effective and gave good results in terms of fertilization rate, clinical pregnancy rate, and live birth rate.

Keywords

In vitro fertilization; Ovarian stimulation; Corifollitropin alfa; Infertility; Embryo transfer

Full Text:

PDF (Tiếng Việt)

References

[1] B. Al Omrani, N. Al Eisa, M. Javed, M. Al Ghedan, H. Al Matrafi, and H. Al Sufyan, "Associations of sperm DNA fragmentation with lifestyle factors and semen parameters of Saudi men and its impact on ICSI outcome," Reproductive Biology Endocrinology, vol. 16, pp. 1-6, 2018.

[2] M.C. Inhorn and P. Patrizio, "Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century," Human reproduction update, vol. 21, no. 4, pp. 411-426, 2015.

[3] V.T. Nguyen et al., Infertility epidemiology and treatment methods. Medical Publishing House, 2010.

[4] Corifollitropin alfa Ensure Study Group, "Corifollitropin alfa for ovarian stimulation in IVF: a randomized trial in lower-body-weight women," Reproductive biomedicine online, vol. 21, no. 1, pp. 66-76, 2010.

[5] T. N. L. Vuong, R. Norman, G. Nhu, H. T. Phung, and M. T. Ho, "Ovulation induction using low-dose step-up rFSH in Vietnamese women with polycystic ovary syndrome," Reproductive biomedicine online, vol. 18, no. 4, pp. 516-521, 2009.

[6] T. N. L. Vuong, R. Norman, G. Nhu, H. T. Phung, and M. T. Ho, "Using long-acting FSH (Corifollitropin Alfa) in in vitro fertilization," Vietnam Journal of Obstetrics and Gynecology, vol. 11, no. 3, pp. 88-92, 2013.

[7] H.T. Phung, "Efficacy of long-acting FSH compared to daily FSH," in IVF expert, 30 Oct 2020.

[8] S. K. Sunkara, V. Rittenberg, N. Raine-Fenning, S. Bhattacharya, J. Zamora, and A. Coomarasamy, "Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles," Human reproduction, vol. 26, no. 7, pp. 1768-1774, 2011.

[9] A. Leader, P. Devroey, H. Witjes et al., “Corifollitropin alfa or rFSH treatment flexibilityoptions for controlled ovarian stimulation: apost hoc analysis of the Engage trial,” Reproductive Biology and Endocrinology, vol. 11, 2013, doi: 10.1186/1477-7827-11-52.

DOI: https://doi.org/10.34238/tnu-jst.9175

Refbacks

There are currently no refbacks.



Remember me