STUDY ON ACUTE TOXICITY AND TREATMENT DIARRHEA OF EXTRACT ANACARDIUM OCCIDENTALE L., ANACARDIACEAE

Abstract

Diarrhea and intestinal hyperactivity are common gastrointestinal motility disorders. They can cause morbidity and mortality, especially in children under 5 years old in developing countries. Anacardium occidentale (Ao) – is a popular tree in Vietnam, especially in the Southeast. In folklore, it is one of the medicinal herbs used to control diarrhea in Africa, especially in Nigeria. However, the studies were mainly carried out on leaves, gum, stem bark, and kernel, but no research on the fruit. The study investigated the acute toxicity and therapeutic effects of the cashew fruit extract on the model of causing diarrhea with castor oil. The results of the study showed that cashew fruit extract is classified into category 6. At the same time, extracts of 250 mg/kg and 500 mg/kg inhibit diarrhea, reducing the number of bowel movements, reducing the number of wet stools, and limiting weight loss equivalent to loperamide at a dose of 4 mg/kg. Cashew fruit extracts 250 mg/kg and 500 mg/kg have therapeutic effects on diarrhea equivalent to loperamide at a dose of 4 mg/kg.