STUDY ON ISOLATION AND STRUCTURAL DETERMINATION OF STEROIDAL SAPONIN FROM THE LEAVES OF Dracaena fragrans

Nguyễn Đức Hùng; Từ Quang Tân; Chu Hoàng Mậu

doi:10.34238/tnu-jst.9402

STUDY ON ISOLATION AND STRUCTURAL DETERMINATION OF STEROIDAL SAPONIN FROM THE LEAVES OF Dracaena fragrans

About this article

Received: 14/12/23 Revised: 05/03/24 Published: 11/03/24

Authors

1. Nguyen Duc Hung , TNU - University of Education
2. Tu Quang Tan, TNU - University of Education
3. Chu Hoang Mau, TNU - University of Education

Abstract

Saponins is a chemical compound which could be found in almost every part of plant. Some saponins such as protodioscin and protoneodioscin have been chosen for the National Cancer Institute’s anticancer drug screen program. Currently, pharmaceutical companies in the world are focusing on searching for new drugs derived from plants, and also finding how to isolate single compounds in order to remove toxic compounds from initial material and collect compounds possessing biological activity including saponins. In this study, a steroidal saponin with a spirostanol aglycone has been isolated from the leaves of Dracaena fragrans. Chemical structure of this compound has been characterized as spirost-5,25(27)-dien-1β,3β-diol-1-O-α-L-rhamnopyranosy-(1→2)-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside, which previously isolated from the stems of Nolina recurvata belonging to the Nolina genus, thus the Asparagaceae family distributed in Japan. A short review on saponins isolated from the Dracaena genus as well as their biological activities has been discussed which further could be used to carry out more experiments on biological activities of spirost-5,25(27)-dien-1β,3β-diol-1-O-α-L-rhamnopyranosy-(1→2)-[β-D-xylopyranosyl-(1→3)]-α-L-arabinopyranoside, in order to complete database on chemical composition and biological activity of D. fragrans and the Dracaena genus.

Keywords

Chemical structure; Dracaena fragrans; NMR; Saponin; Spirostane-type

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DOI: https://doi.org/10.34238/tnu-jst.9402

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