EFFECTS OF GELLING AGENT ON THE RELEASE  OF ACTIVE INGREDIENTS FROM MICROEMULSION GEL COMBINE CURCUMIN AND CLINDAMYCIN

Đặng Thị Huyền; Lê Hậu; Huỳnh Văn Chung; Lê Trung Khoảng; Hoàng Thị Thu Huyền; Hà Hoàng Anh Vĩnh; Hoàng Thị Minh Thu

doi:10.34238/tnu-jst.9530

EFFECTS OF GELLING AGENT ON THE RELEASE OF ACTIVE INGREDIENTS FROM MICROEMULSION GEL COMBINE CURCUMIN AND CLINDAMYCIN

About this article

Received: 03/01/24 Revised: 05/03/24 Published: 12/03/24

Authors

1. Dang Thi Huyen , Faculty of Pharmacy - Buon Ma Thuot Medical University
2. Le Hau, Faculty of Pharmacy - University of Medicine and Pharmacy at HCMC
3. Huynh Van Chung, Faculty of Pharmacy - Buon Ma Thuot Medical University
4. Le Trung Khoang, Faculty of Pharmacy - Buon Ma Thuot Medical University
5. Hoang Thi Thu Huyen, Faculty of Pharmacy - Buon Ma Thuot Medical University
6. Ha Hoang Anh Vinh, Faculty of Pharmacy - Buon Ma Thuot Medical University
7. Hoang Thi Minh Thu, Faculty of Pharmacy - Buon Ma Thuot Medical University

Abstract

This study aimed to investigate the effect of gelling agents on the release of active ingredients from microemulsion gel containing curcumin and clindamycin. Microemulsion gel combined with clindamycin and curcumin is prepared with gelling agent hyaluronic acid and carbopol 940 at appropriate concentrations. The evaluation of the ability to release active ingredients was performed with a vertical Franz cell, cellulose membrane 0.45 µm and quantified using high-performance liquid chromatography method. The higher concentration of gelling agent in the gel formulation, the less likely it is to release the active ingredients through the cellulose acetate membrane. With carbopol 940, the gel concentration 0.1% makes the gel with the best ability of release curcumin through the cellulose acetate membrane. The amount of curcumin released after 0.5 hour, 1 hour, 2 hours, 3 hours, and 5 hours of the gel was 10.14 µg/cm², 29.98 µg/cm², 56.49 µg/cm², 75.97 µg/cm², 119.06 g/cm², respectively. With gel dosage forms, gelling agent types and the concentration of gelling agent are factors that determine the ability to release active ingredients.

Keywords

Gelling agent; Microemulsion gel; Active release; Curcumin; Clindamycin

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DOI: https://doi.org/10.34238/tnu-jst.9530

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