PREVALENCE AND ANTIBIOTIC RESISTANCE OF STREPTOCOCCUS PNEUMONIAE AND HAEMOPHILUS INFLUENZAE CAUSE PNEUMONIA IN 2 MONTHS TO 5 YEARS OLD CHILDREN AT THAI NGUYEN NATIONAL HOSPITAL

Lường Trà My; Lê Thị Kim Dung

doi:10.34238/tnu-jst.11038

PREVALENCE AND ANTIBIOTIC RESISTANCE OF STREPTOCOCCUS PNEUMONIAE AND HAEMOPHILUS INFLUENZAE CAUSE PNEUMONIA IN 2 MONTHS TO 5 YEARS OLD CHILDREN AT THAI NGUYEN NATIONAL HOSPITAL

About this article

Received: 29/08/24 Revised: 17/12/24 Published: 18/12/24

Authors

1. Luong Tra My , TNU – University of Medicine and Pharmacy
2. Le Thi Kim Dung, TNU – University of Medicine and Pharmacy

Abstract

Streptococcus pneumoniae and Haemophilus influenzae are the most common causes of bacterial pneumonia in children. This study was about prevalence and antibiotic resistance of Streptococcus pneumoniae and Haemophilus influenzae cause pneumonia in children at Thai Nguyen National Hospital. This was a cross-sectional descriptive study, including 540 children from 2 months to 5 years old diagnosed with pneumonia according to Ministry of Health standards 2014, admitted to the Thai Nguyen National Hospital from July 1, 2023 to June 30, 2024. The results showed that: 30.6% case of isolating pathogenic bacteria. In which, Streptococcus pneumoniae is the most common cause of bacterial pneumonia (65.4%), Haemophilus influenzae are the second common cause accounting for 16.4%. Streptococcus pneumoniae và Haemophilus influenzae are common in 12 months to 5 years old children. The antibiotic resistance rate of Streptococcus pneumoniae was very high: Erythromycin 100%, Clindamycin 97%, Tetracyclin 89.8%, Co-trimoxazole 64.4%. However, Streptococcus pneumoniae was sensitive to Linezolid 100%, Vancomycin 98.8%, Levofloxacin 98.0%. Haemophilus influenzae had high rate of resistance to Azithromycin 66.7%, Co-trimoxazole and Ampicillin 65.2%, sensitivity to Ciprofloxacin 63%, Imipenem 56%. Streptococcus pneumoniae and Haemophilus influenzae are common causes bacterial pneumonia in 2 months to 5 years old children, especially in children from 12 months to 5 years old. Streptococcus pneumoniae and Haemophilus influenzae had a high rate of resistance to common antibiotics used to treatment pneumonia.

Keywords

Pneumonia; Streptococcus pneumoniae; Haemophilus influenzae; Children; Antibiotic resistance

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References

[1] J. Perin et al., "Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals," Lancet Child Adolesc Health, vol. 6, no. 2, pp. 106-115, Feb 2022.

[2] WHO, "Pneumonia in children," 2022. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/pneumonia. [Accessed Aug. 8, 2024].

[3] Ministry of Health, "Guidelines for the treatment of community - acquired pneumoniae in children. Decision No. 101/QD - BYT dated January 9, 2014," Ministry of Health, Hanoi 2014.

[4] T. H. N. Duong, T. N. M. Khong, and T. K. D. Le, "Etiology and level of antibiotic resistance of bacteria causing pneumonia in 2 months to 5 years old children at Thai Nguyen National Hospital in 2019-2020," Vietnam Journal of Preventive Medicine, vol. 30, no. 6, pp. 9-15, 2020.

[5] T. V. N. Truong, "Antibiotic resistance of Haemophilus influenzae and treatment results in pneumonia due to Haemophilus influenzae in Vietnam National Children's Hospital," Master's thesis in medicine, Thainguyen University of Medicine and Pharmacy, 2022.

[6] D. Q. Nguyen, M. T. Dao, Q. P. Bui, and T. V. N. Truong, "Antibiotic resistance of Streptococcus pneumoniae and treatment results pneumococcal pneumonia in children at the Vietnam National Children;s Hospital," Journal of Pediatric Research and Practice, vol. 5, no. 4, pp. 27-34, 2021.

[7] N. Q. Do and T. T. Nguyen, "Microbiology cause pneumonia in children 2 months to 5 years old at Thai Nguyen Central Hospital," Vietnam Medical Journal, vol. 505, no. 2, pp. 225-228, 2021.

[8] T. H. Vu, C. T. Bui, T. C. Mai, and T. D. T. Nguyen, "Etiology of pneumonia in children less than 5 years of age at the general department B, Vietnam National Children's Hospital," Vietnam Medical Journal, vol. 468, no. 2, pp. 126-129, 2018.

[9] T. H. Le, D. V. Tran, and T. Y. Nguyen, "Prevalence and etiologies of bacterial pneumonia in children under 5 years old at Thanh Hoa Children's Hospital," Vietnam Medical Journal, vol. 517, no. 1, pp. 163-166, 2022.

[10] W. Mai, Y. Liu, Q. Meng, J. Xu, and J. Wu, "Bacterial Epidemiology and Antimicrobial Resistance Profiles of Respiratory Specimens of Children with Pneumonia in Hainan, China," Infect Drug Resist, vol. 16, pp. 249-261, 2023.

[11] T. T. H. Nguyen, "Clinical epidemiological characteristics and treatmemt results pneumococcal pneumonia in children under 5 years old at Thai Nguyen National Hospital," Master's thesis in medicine, Thainguyen University of Medicine and Pharmacy, 2020.

[12] T. L. Hoang, T. D. T. Nguyen, T. N. Pham, and V. N. Phan, "Antibiotic susceptibility and treatment results for pneumococcal pneumonia at the Thanh Hoa Children's Hospital period 2021 - 2022," Vietnam Medical Journal, vol. 516, no. 2, pp. 276-279, 2022.

[13] T. T. Tran and T. P. N. Ngo, "Antibiotic sensitivity, clinical and para-clinical features of pneumonia due to Haemophilus influenzae in children," Journal of Medical Research, vol. 80, no. 3A, pp. 153-158, 2012.

[14] D. Torumkuney et al., "Results from the Survey of Antibiotic Resistance (SOAR) 2016-18 in Vietnam, Cambodia, Singapore and the Philippines: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints," J Antimicrob Chemother, vol. 75, no. 1, pp. i19-i42, 2020.

DOI: https://doi.org/10.34238/tnu-jst.11038

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