STUDY ON OPTIMIZATION OF AN ULTRASOUND-ASSISTED EXTRACTION CONDITION OF FLAVONOID FROM PASSIFLORA FOETIDA L.  USING RESPONSE SURFACE METHODOLOGY

Lành Thị Ngọc; Vũ Thị Thu Lê

doi:10.34238/tnu-jst.12258

STUDY ON OPTIMIZATION OF AN ULTRASOUND-ASSISTED EXTRACTION CONDITION OF FLAVONOID FROM PASSIFLORA FOETIDA L. USING RESPONSE SURFACE METHODOLOGY

About this article

Received: 10/03/25 Revised: 03/04/25 Published: 04/04/25

Authors

1. Lanh Thi Ngoc, TNU - University of Agriculture and Forestry
2. Vu Thi Thu Le , TNU - University of Agriculture and Forestry

Abstract

This study aims to optimize the extraction conditions of total flavonoids from Passiflora foetida L. by ultrasonic extraction. The experimental design was carried out according to the Box-Benhken design. Using the response surface methodology (RSM), an optimization model of the extraction process was built with two objective functions: extraction efficiency (Y1) and total flavonoid content (Y2). Four technological factors, including ethanol concentration, ultrasonic power, extraction time and extraction ratio were studied. The results showed that the experimental data were fit to a second-order polynomial model using correlation analysis of the mathematical regression model. According to the built model, the optimal conditions were calculated as: ethanol concentration 75% (v/v), extraction time 42 (min), ultrasonic power 179 (W) and extraction ratio 20/1 (mL/g). Under optimal conditions, the extraction efficiency and total flavonoid content reached values of 15.48 ± 0.17% and 2.43 ± 0.11%, respectively.

Keywords

Passiflora foetida L.; Response surface methodology; Total flavonoid content; Optimization; Ultrasound assisted extraction

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DOI: https://doi.org/10.34238/tnu-jst.12258

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