ISOLATION OF COMPOUNDS FROM COPTIS CHINENSIS ROOTS

Bùi Thị Nhật Lệ; Nguyễn Thị Thu Minh; Đỗ Hoàng Giang; Nguyễn Thị Luyến; Nguyễn Thu Uyên; Hoàng Thùy Dương; Lưu Hải Nhi; Trương Ngọc Minh; Vũ Đức Nam; Tsvetelina Doncheva; Cao Thanh Hải; Ngô Thị Thúy Ngân; Nguyễn Tiến Đạt

doi:10.34238/tnu-jst.12611

ISOLATION OF COMPOUNDS FROM COPTIS CHINENSIS ROOTS

About this article

Received: 17/04/25 Revised: 04/08/25 Published: 04/08/25

Authors

1. Bui Thi Nhat Le, 1) Center for High Technology Research and Development - Vietnam Academy of Science and Technology; 2) Graduate University of Science and Technology - Vietnam Academy of Science and Technology
2. Nguyen Thi Thu Minh, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
3. Do Hoang Giang, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
4. Nguyen Thi Luyen, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
5. Nguyen Thu Uyen, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
6. Hoang Thuy Duong, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
7. Luu Hai Nhi, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
8. Truong Ngoc Minh, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
9. Vu Duc Nam, Center for High Technology Research and Development - Vietnam Academy of Science and Technology
10. Tsvetelina Doncheva, Institute of Organic Chemistry with Centre of Phytochemistry - Bulgarian Academy of Sciences
11. Cao Thanh Hai, TNU - University of Sciences
12. Ngo Thi Thuy Ngan, TNU - University of Medicine and Pharmacy
13. Nguyen Tien Dat , Center for High Technology Research and Development - Vietnam Academy of Science and Technology

Abstract

Coptis chinensis Franch., a species belonging to the genus Coptis in the family Ranunculaceae, is a rare medicinal plant renowned for its high pharmaceutical value. It is particularly rich in alkaloids, which are recognized as its principal bioactive constituents. These compounds exhibit a wide range of pharmacological activities, including anti-inflammatory, antitumor, antibacterial, antifungal, antidiabetic, and anti-Alzheimer's activities. In this study, compounds were isolated and characterized from the rhizome of C. chinensis using column chromatography, thin-layer chromatography, semi-preparative high-performance liquid chromatography, and nuclear magnetic resonance spectroscopy. As a result, five compounds were successfully isolated, including three alkaloids- noroxyhydrastine (1), berberine (2), and jatrorrhizine (3); and two non-alkaloid compounds - p-coumaric acid (4), a phenolic acid, and vomifoliol (5), an apocarotenoid. These findings contribute to the phytochemical profile of C. chinensis and enhance the current understanding of alkaloid-rich plant species in Vietnam, particularly within the Coptis genus.

Keywords

Coptis chinensis Franch.; Alkaloid; Isoquinoline alkaloid; Non-alkaloid; Bioactive constituents

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DOI: https://doi.org/10.34238/tnu-jst.12611

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