SELECTION OF OPTIMIZED NANO EMULSION FORMULATION CONTAINING CURCUMINE

Abstract

Curcumin is a natural active composition used for effection and cancer, however, it has low bioavailability because of its dissolution in water in oral route, with its advantages that are easier to prepare, more stable, and small size of droplet, the nanoemulsion easily go through intestinal walls into blood and the bioavailability of curcumin in oral route could be improved. Base on recent results of the effective factors on droplet sizes of nanoemulsion, MODDE and Inform were used to optimize the formulation of curcumin nanoemulsion.  Nanoemulsion comprising curcumin was prepared with an emulsion method with supporting high-speed homogenizer and ultrasound waves. The size of droplets and stability were evaluated by the micro crops method. The results showed that drops size of nanoemulsion was clearly affected by the amount of Tween 80 but not by amount of polyethylene glycol 400 that had almost effected on stability. So that the formulation of nanoemulsion containing curcumin was optimized and chosen.