Email this article STUDY ON PREPARATION OF GRANULATED CONTAINING POLYPHENOL, CURCUMIN EXTRACTED FROM GREEN TEA AND CURCUMA LONGA.
About this article
Received: 06/01/20 Revised: 05/02/20 Published: 11/06/20Authors
1. Nguyen Khac Tung
, TNU - University of Medicine and Pharmacy2. Nguyen Thu Quynh, TNU - University of Medicine and Pharmacy
3. Dao Thuy Linh, TNU - University of Medicine and Pharmacy
4. Dong Quang Huy, TNU - University of Medicine and Pharmacy
Abstract
The study was conducted to formulate of granulated medicine containing extracts of curcuma longa L and green tea. Green tea is extracted by hot soaking method, with acidic water solution having pH 3.0. Curcuma longa L is extracted by immersion method using an infused flask, with the solvent being 70% acetone. The ratio of medicinal herbs to the solvent is 1:10. The extraction time is 4 hours with twice extraction. After removing impurities and drying process, the product is ground into powder consisting of green tea (about 41% polyphenol content) and curcuma longa L (about 92% curcumin content). A solid dispersion system of curcuma longa L extract is prepared by melting method. Granulated medicine is prepared by wet granulation method with the ratio of green tea to solid dispersion system curcuma longa to glucose being 1:3.75:8; binder and lubricant excipients used are 96% ethanol and magnesium stearate and talc, respectively. The product obtained is yellow brown, dry, sweet, having less than five-minute decomposition, <5% moisture content and equitable mass ranging within ± 7.5% of the average mass of the packages.
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