METHOD DEVELOPMENT FOR DETERMINATION OF INORGANIC IMPURITIES IN WASTEWATER FROM METHAMPHETAMINE SYNTHESIS USING INDUCTIVELY COUPLED PLASMA - MASS SPECTROMETRY (ICP-MS)

Vũ Tùng Lâm; Đặng Thị Ngọc Lan; Nguyễn Thị Thuỳ Linh; Phạm Lê Minh; Hoàng Ngọc Mai; Nguyễn Xuân Trường; Trần Nguyên Hà

doi:10.34238/tnu-jst.7135

METHOD DEVELOPMENT FOR DETERMINATION OF INORGANIC IMPURITIES IN WASTEWATER FROM METHAMPHETAMINE SYNTHESIS USING INDUCTIVELY COUPLED PLASMA - MASS SPECTROMETRY (ICP-MS)

About this article

Received: 18/12/22 Revised: 11/01/23 Published: 11/01/23

Authors

1. Vu Tung Lam, Hanoi University of Pharmacy
2. Dang Thi Ngoc Lan, Hanoi University of Pharmacy
3. Nguyen Thi Thuy Linh, Hanoi University of Pharmacy
4. Pham Le Minh, Hanoi University of Pharmacy
5. Hoang Ngoc Mai, Institute of Forensic Sciences
6. Nguyen Xuan Truong, Institute of Forensic Sciences
7. Tran Nguyen Ha , Hanoi University of Pharmacy

Abstract

The inorganic impurities are essential in the synthesis of methamphetamine, and might be present in wastewater near the production site. The determination of these elements therefore, may contribute useful information for the investigation of illegal methamphetamine production. In this study, ICP-MS was used to quantify 7 inorganic impurities (Li, B, Al, Ni, Zn, Pd, Pt) in wastewater with analysis conditions: plasma flow rate: 15.0 L/min, RF source capacity:1.5 kW, sample depth 5.5 mm. Simple sample preparation using HNO₃ was used. The method was validated according to AOAC 2016 guidelines. The selectivity and repeatability was adequate, as well as for linearity within the investigated concentrations of 1 - 250 ppb for Li, Ni; 5 - 250 ppb for B, Pd, Pt; 25 - 500 ppb for Al and 10 - 500 ppb for Zn. LOD ranged from 0.2 ppb to 7.6 ppb; LOQ from 0.8 ppb to 25.3 ppb. The recovery was 82.4 - 118.2 % with the concentration 10 ppb - 500 ppb; 87.3 - 109.3 % with the concentration 1 ppb - 10 ppb.

Keywords

Methamphetamine; Determination; Inorganic impurities; ICP-MS; Wastewater

Full Text:

PDF (Tiếng Việt)

References

[1] H. A. Nguyen, V. H. Truong, M. S. Nguyen, and M. G. Le, "Methamphetamine use and related factors among men who sell sex to men in three cities, Vietnam, 2011," (in Vietnamese), Journal of Preventive Medicine, vol. XXV, no. 6 (166), pp. 300 – 307, 2015.

[2] S. C. Wilschefski and M. R. Baxter, "Inductively Coupled Plasma Mass Spectrometry: Introduction to Analytical Aspects," Clinical Biochemist Reviews, vol. 2019, no. 40 (iii), pp. 115-133, 2019.

[3] C. H. Pham, M. C. Nguyen, T. M. H. Lu, N. T. Tran, T. G. Pham, V. T. Le, V. P. Phung, V. C. Dinh, and V. H. Le, “Simultaneous analysis of metals in various types medicinal herbs commonly use to produce functional foods by ICP – MS," (in Vietnamese), Vietnam Journal of Food Control, vol. 3, no. 1, pp. 29-37, 2020

[4] Y. Huang, A. A. Keller, P. Cervantes-Avilés, and J. Nelson, "Fast Multielement Quantification of Nanoparticles in Wastewater and Sludge Using Single-Particle ICP-MS," ACS ES&T Water, vol. 1, no. 1, pp. 205-213, 2021.

[5] Y. Zhang, L. Li, Q. Wang, M. Shen, W. Han, X. Yang, L. Chen, A. Ma, and Z. Zhou "Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS," Analytical and Bioanalytical Chemistry, vol. 411, no. 15, pp. 3361-3372, 2019.

[6] D. Langone, B. Painter, C. Nash, J. Hulshof, S. Oldenhof, M. R. Johnston, and K. P. Kirkbride, "Impurity profiling of methamphetamine synthesized from methyl α-acetylphenylacetate," Drug Testing and Analysis, vol. 14, no. 7, pp. 1310-1324, 2022.

[7] T. H. Tran, H. M. Le, and V. T. Nguyen, “Determination of the traces of heavy metals in the West Lake - Hanoi by ICP-MS,” (in Vietnamese), Journal of Analytical Sciences, vol. 13, no. 2, pp. 111-115, 2008.

[8] M. T. Hoang, Q. T. Nguyen, V. N. Le, N. T. Nguyen, T. P. T. Pham, T. T. Pham, and D. N. Vu, "Determination of the analytical produce of heavy metals in alcohol beverages in Vietnam using ICP-MS method," (in Vietnamese), Journal of Analytical Sciences, vol. 22, no. 4, pp. 53-61, 2017.

DOI: https://doi.org/10.34238/tnu-jst.7135

Refbacks

There are currently no refbacks.



Remember me