EVALUATION OF THE THERAPEUTIC SUPPORT POTENTIAL ON TYPE II DIABETES DISEASE CONTAINED IN Zingiber officinale Roscoe BY MOLECULAR DOCKING METHOD

Trần Đại Luật; Cao Bá Cường; La Việt Hồng; Cao Phi Bằng

doi:10.34238/tnu-jst.8814

EVALUATION OF THE THERAPEUTIC SUPPORT POTENTIAL ON TYPE II DIABETES DISEASE CONTAINED IN Zingiber officinale Roscoe BY MOLECULAR DOCKING METHOD

About this article

Received: 24/09/23 Revised: 30/10/23 Published: 07/11/23

Authors

1. Tran Dai Luat, Hanoi Pedagogical University 2
2. Cao Ba Cuong , Hanoi Pedagogical University 2
3. La Viet Hong, Hanoi Pedagogical University 2
4. Cao Phi Bang, Hung Vuong University

Abstract

Diabetes is a convulsive metabolism with main characterization that is increasing glucose in blood because of lack of absolute insulin or relative insulin/ or decreasing function of insulin. The growing extent of the blood sugar state leads to complications in big blood vessels and small blood vessels due to the insulin excretion shortage from pancreatic β cells or the action ability of insulin. Protein tyrosine phosphatase 1B(PTP1B) catalyzed the removal phosphate group process of insulin receptor ensue was reducing efficiention of insulin to target issues. Accordingly, PT1B overcoming is efficient for treating diabetic disease. In this study, the docking molecule method was used to screen compounds in Ginger having functions that overcome PTP1B for application to therapeutic type II diabetes disease. After the screening process, α-Gurjunene is a compound having complete additions for application to therapeutic type II diabetes disease based on prediction parameters.

Keywords

α-Gurjunene; Diabetes disease; Docking molecule; PT1B; Zingiber officinale Roscoe

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DOI: https://doi.org/10.34238/tnu-jst.8814

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