DETERMINATION OF PROCALCITONIN AND LACTATE EHYDROGENASE CONCENTRATIONS AND THEIR RELATIONSHIP WITH SEVERITY IN PEDIATRIC PATIENTS WITH SEVERE INFECTIONS TREATED  AT THE THAI NGUYEN NATIONAL HOSPITAL

Dương Thị Hoa; Lê Thị Hương Lan; Nguyễn Thành Trung; Vũ Tuấn Anh

doi:10.34238/tnu-jst.8936

DETERMINATION OF PROCALCITONIN AND LACTATE EHYDROGENASE CONCENTRATIONS AND THEIR RELATIONSHIP WITH SEVERITY IN PEDIATRIC PATIENTS WITH SEVERE INFECTIONS TREATED AT THE THAI NGUYEN NATIONAL HOSPITAL

About this article

Received: 08/10/23 Revised: 14/11/23 Published: 15/11/23

Authors

1. Duong Thi Hoa, TNU - University of Medicine and Pharmacy
2. Le Thi Huong Lan , Thai Nguyen National hospital
3. Nguyen Thanh Trung, Thai Nguyen National hospital
4. Vu Tuan Anh, Thai Nguyen National hospital

Abstract

The study aimed to determine about procalcitonin (PCT) and lactate dehydrogenase (LDH) concentrations and their relationship with severe prognosis in pediatric patients with severe infections. The subject of this study included 38 patients who were diagnosed with severe infections at the pediatric center of Thai Nguyen National Hospital from July 2022 to July 2023. This method was a descriptive cross-sectional study. The results showed that: the highest proportion of male children (63.2%), age group < 12 months (76.3%), rural areas (76.3%), the most common initial infection site is respiratory infection (65.8%). Among the patients studied, PCT increased by 100%, and the average PCT concentration at the time of diagnosis was 16.14 ± 24.52 ng/ml. In the ROC analysis at the time of diagnosis, the area under the curve of PCT was 0.818; 0.714 for LDH. In patients diagnosed with severe infections, PCT and LDH have the ability to predict severity at a relatively good level, with cutoff concentrations of 12.08 ng/ml for PCT with sensitivity of 80.0% and specificity of 85.7% and 745.5% for LDH with sensitivity of 60.0% and specificity of 82.1%.

Keywords

Severe infection; Procalcitonin; Lactate dehydrogenase; Septic shock; Poor prognosis

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DOI: https://doi.org/10.34238/tnu-jst.8936

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