CLINICAL AND SUBCLINICAL CHARACTERISTICS OF THE PATIENTS DENGUE HEMORRHAGIC FEVER IN THAI NGUYEN | Nga | TNU Journal of Science and Technology

CLINICAL AND SUBCLINICAL CHARACTERISTICS OF THE PATIENTS DENGUE HEMORRHAGIC FEVER IN THAI NGUYEN

About this article

Received: 25/09/23                Revised: 14/11/23                Published: 15/11/23

Authors

1. Luong Thi Quynh Nga Email to author, TNU - University of Medicine and Pharmacy
2. Duong Van Thanh, TNU - University of Medicine and Pharmacy
3. Nguyen Thi Tuyet, TNU - University of Medicine and Pharmacy

Abstract


We conducted a retrospective study on 43 patients diagnosed with dengue hemorrhagic fever (DHF) according to the standards of the Ministry of Health in 2019. Ourobjective is describing the epidemiological, clinical, and subclinical characteristics of patients with (DHF) in Thai Nguyen.The results showed that,patients with age 35 - ≤ 60 was accounted for 58.1%, age ≤ 16 was 4.6%. Patients live in 15/21 wards; 01/11 communes in Thai Nguyen city; 4/6 districts include Phu Binh, Vo Nhai, Dai Tu; Dong Hy. The proportion of patients with symptoms of fever was 100%, bleeding was 31/43 (72.1%), abdominal pain in the liver or tenderness was 10/43 (23.2%), vomiting was 7/43 (16.3%), diarrhea (9.3%), pleural effusion and acites (4.6%). Patients with a hematocrit of 35-45% were 21/43 (48.8%); hematocrit > 45% accounted for 20/43 (46.6%). Patients with platelet 5- < 50 accounted for 22/43 (51.2%); 20/43 (46.5%) patients had platelets reduced from 50 - < 150 G/l; No patient had platelets < 5 G/l. Patients with AST and ALT of 40 - < 400 (U/l) accounted for the highest proportion of 35/43 (81.4%) and 30/43 (69.8%), respectively. 2/43 (4,6%) patients with AST ≥ 1000 (U/l); 1/43 (2.3%) patients had ALT ≥ 1000 (U/l). 100% patients in the study were cured and discharged from the hospital, mainly patients with DHF and DHF with warning signs.

Keywords


Dengue hemorrhagic fever; Epidermiology; Clinical; Subclinical; Thai Nguyen

References


[1] Ministry of Health, "Guidelines for diagnosis and treatment of dengue hemorrhagic fever," Decision No. 3705/QD-BYT Issued according to Minister of Health dated August 22, 2019, 2019.

[2] WHO, “Dengue guidelines for diagnosis, treatment, prevention and control,” ed. France: WHO press, pp. 1-160, 2009.

[3] S. K. Roy and S. Bhattacharjee, "Dengue virus: epidemiology, biology, and disease aetiology," Canadian Journal of Microbiology, vol. 67, no. 10, pp. 687-702, 2021.

[4] P. D. N. N. Sirisena, S. Mahilkar, C. Sharma, J. Jain, and S. Sunil, "Concurrent dengue infections: Epidemiology & clinical implications," Indian Journal of Medical Research, vol. 154, no. 5, pp. 669-679, 2021.

[5] A. C. A. C. T. Tsheten , D. J. Gray, R. K. Adhikary, L. Furuya‑Kanamori, and K. Wangdi, "Clinical predictors of severe dengue: a systematic review and meta-analysis," Infectious Diseases of Poverty, vol. 10, no. 123, pp. 1-10, 2021.

[6] V. T. Duangjai Sahassananda, P. Chonsawat, S. C. Benjamaporn Wongphan, M. Surabotsophon, and A. V. Desakorn, "Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System," Journal of Tropical Medicine, 2021, Art. no. 8852031.

[7] S. Malik, O. A.-O. Ahsan, H. Mumtaz, M. A.-O. Tahir Khan, R. A.-O. Sah, and Y. A.-O. Waheed, "Tracing down the Updates on Dengue Virus-Molecular Biology, Antivirals, and Vaccine Strategies," Vaccines, vol. 11, no. 8, 2023, Art. no. 1328.

[8] WHO, Regional Office for South-East Asia, Dengue Bulletin, vol. 39, pp. 1-121, 2016.

[9] WHO, "Dengue and severe dengue," 2023. [Online]. Available: https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue. [Accessed March 17, 2023].

[10] Ministry of Health, " More than 66,000 cases, 14 patients died from dengue fever, which type of virus causes this disease this year," 2023. [Online]. Available: https://moh.gov.vn/tin-lien-quan/- /asset_publisher/vjYyM7O9aWnX/content/ More than 66,000 cases, 14 patients died from dengue fever, which type of virus causes this disease this year. [Accessed August 31, 2023].

[11] D. K. T. Tran, L. P. Hoang, T. T. N. Tran, T. G. Phan, Q. H. L, V. N. Nguyen, et al., "Clinical, epidemiological and virological features of Dengue virus infections in Vietnamese patients presenting to primary care facilities with acute undifferentiated fever," Journal of Infection, vol. 60, pp. 229-237, 2010.

[12] T. T. Nguyen, D. C. Do, X. L. Le, T. H. Dinh, M. Lindeborg, V. H. Nguyen, et al., "Risk factors of dengue fever in an urban area in Vietnam: a case-control study," BMC Public Health, vol. 21, p. 664, 2021.

[13] S. Sangkaew, D. Ming, A. Boonyasiri, K. Honeyford, S. Kalayanarooj, S. Yacoub et al., "Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis," Lancet Infectious Disease, vol. 21, pp. 1014-1026, 2021.

[14] T. Tsheten, A. C. A. Clements, D. J. Gray, R. K. Adhikary, L. Furuya-Kanamori, and K. Wangdi, "Clinical predictors of severe dengue: a systematic review and meta-analysis," Infectious Diseases of Poverty, vol. 10, p. 123, 2021.

[15] Deborah Ng., J. G. Wong, T. L. Thein, Y. S. Leo, and D. C. Lye, "The Significance of Prolonged and Saddleback Fever in Hospitalised Adult Dengue," PLoS One, vol. 11, 2016, Art. no. e0167025.




DOI: https://doi.org/10.34238/tnu-jst.8824

Refbacks

  • There are currently no refbacks.
TNU Journal of Science and Technology
Rooms 408, 409 - Administration Building - Thai Nguyen University
Tan Thinh Ward - Thai Nguyen City
Phone: (+84) 208 3840 288 - E-mail: jst@tnu.edu.vn
Based on Open Journal Systems
©2018 All Rights Reserved